ID   DENR_XENLA              Reviewed;         198 AA.
AC   Q6GLZ1;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Density-regulated protein;
DE            Short=DRP;
GN   Name=denr;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the translation of target mRNAs by
CC       scanning and recognition of the initiation codon. Involved in
CC       translation initiation; promotes recruitment of aminoacetyled initiator
CC       tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA
CC       and mRNA from recycled 40S subunits following ABCE1-mediated
CC       dissociation of post-termination ribosomal complexes into subunits (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DENR family. {ECO:0000305}.
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DR   EMBL; BC074302; AAH74302.1; -; mRNA.
DR   RefSeq; NP_001086186.1; NM_001092717.1.
DR   AlphaFoldDB; Q6GLZ1; -.
DR   SMR; Q6GLZ1; -.
DR   BioGRID; 102778; 1.
DR   IntAct; Q6GLZ1; 1.
DR   DNASU; 444615; -.
DR   GeneID; 444615; -.
DR   KEGG; xla:444615; -.
DR   CTD; 444615; -.
DR   Xenbase; XB-GENE-1002805; denr.L.
DR   OrthoDB; 1490022at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 444615; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR005873; DENR_eukaryotes.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   Pfam; PF01253; SUI1; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   TIGRFAMs; TIGR01159; DRP1; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..198
FT                   /note="Density-regulated protein"
FT                   /id="PRO_0000130605"
FT   DOMAIN          115..182
FT                   /note="SUI1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00200"
FT   REGION          76..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  22220 MW;  0B5417F2FBEBC83B CRC64;
     MASTAIENAE PSDCKADLKI PKIDGDFPLK VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN
     FPDVFAKLTL GHIPKQETGT VEGQATSGEE EEKKKQKRGG RGQIKQKKKT VPQRITIAKI
     PRAKKKYVTR VCGLATFEIE LKDAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE
     KWPEVDDDSI EDLGEVKK