3BP5H_DROME
ID 3BP5H_DROME Reviewed; 477 AA.
AC Q9V785;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 4.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=SH3 domain-binding protein 5 homolog;
DE AltName: Full=Protein parcase;
GN Name=pcs; ORFNames=CG7761;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113 AND SER-115, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58174.5; -; Genomic_DNA.
DR EMBL; AY058328; AAL13557.1; -; mRNA.
DR RefSeq; NP_611010.4; NM_137166.5.
DR AlphaFoldDB; Q9V785; -.
DR SMR; Q9V785; -.
DR BioGRID; 62415; 25.
DR IntAct; Q9V785; 2.
DR STRING; 7227.FBpp0290722; -.
DR iPTMnet; Q9V785; -.
DR PaxDb; Q9V785; -.
DR DNASU; 36674; -.
DR EnsemblMetazoa; FBtr0301507; FBpp0290722; FBgn0033988.
DR GeneID; 36674; -.
DR KEGG; dme:Dmel_CG7761; -.
DR UCSC; CG7761-RA; d. melanogaster.
DR CTD; 36674; -.
DR FlyBase; FBgn0033988; pcs.
DR VEuPathDB; VectorBase:FBgn0033988; -.
DR eggNOG; KOG2008; Eukaryota.
DR GeneTree; ENSGT00390000018500; -.
DR HOGENOM; CLU_043711_2_1_1; -.
DR InParanoid; Q9V785; -.
DR OMA; AQIECQK; -.
DR OrthoDB; 566222at2759; -.
DR PhylomeDB; Q9V785; -.
DR SignaLink; Q9V785; -.
DR BioGRID-ORCS; 36674; 0 hits in 3 CRISPR screens.
DR ChiTaRS; pcs; fly.
DR GenomeRNAi; 36674; -.
DR PRO; PR:Q9V785; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033988; Expressed in saliva-secreting gland and 46 other tissues.
DR Genevisible; Q9V785; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:FlyBase.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:FlyBase.
DR GO; GO:0007301; P:female germline ring canal formation; IMP:FlyBase.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0007498; P:mesoderm development; IMP:FlyBase.
DR GO; GO:0042694; P:muscle cell fate specification; IMP:FlyBase.
DR GO; GO:0007517; P:muscle organ development; IMP:FlyBase.
DR GO; GO:0048644; P:muscle organ morphogenesis; IMP:FlyBase.
DR GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IGI:FlyBase.
DR InterPro; IPR007940; SH3BP5.
DR PANTHER; PTHR19423; PTHR19423; 1.
DR Pfam; PF05276; SH3BP5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome; SH3-binding.
FT CHAIN 1..477
FT /note="SH3 domain-binding protein 5 homolog"
FT /id="PRO_0000064367"
FT REGION 224..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..95
FT /evidence="ECO:0000255"
FT COILED 122..221
FT /evidence="ECO:0000255"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 477 AA; 53766 MW; 7A3013DCF7987230 CRC64;
MSSAEDGELD PQIQIELENL NSATDEINKL EIELEEANST FRILLNESTR RLKVSSKKLG
NCIEKARPYY EALDKAREAQ IECQKAAVKF QRANEIHAAA KETVALAEQR FMSNSHEWQF
DNAWQEMLNH ATQKVMDAET QKADCHAEHQ RLTKLFNAAE QKLQQLEDRF RRSINKSRPY
FEEKQVCQDQ LQTQKNRIQE LQQQVAGAKS TYSTALRNLE RISEDIHRQR GDFPTPPGPR
EPGVGAELNS PTSSALPSLP DFQLELEKCD YPSIAGSQMS LGAKTPQAAA ETEDEEDACD
YDETGAGELR GVVDERDLEA LRQKVKILAV RPIEGGDGQQ QNDVWEHELK ATVDKLDHLM
MLKETAKRQQ TNRLKSTEQR PDSLGAEALK RHCDVVEVKV TSCATTASLP VTPHHQLNHL
APPTPIKKLQ QQLAPLPSVN VSMRELPLLA RLSNELLDRS SAAFGGVRKT LRRRSLE
