ID   3BP5L_BOVIN             Reviewed;         385 AA.
AC   Q0V8K7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=SH3 domain-binding protein 5-like;
DE            Short=SH3BP-5-like;
GN   Name=SH3BP5L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for
CC       RAB11A. {ECO:0000250|UniProtKB:Q7L8J4}.
CC   -!- SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000305}.
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DR   EMBL; BC119925; AAI19926.1; -; mRNA.
DR   EMBL; BT026211; ABG67050.1; -; mRNA.
DR   RefSeq; NP_001069270.1; NM_001075802.1.
DR   AlphaFoldDB; Q0V8K7; -.
DR   SMR; Q0V8K7; -.
DR   STRING; 9913.ENSBTAP00000003422; -.
DR   PaxDb; Q0V8K7; -.
DR   PRIDE; Q0V8K7; -.
DR   Ensembl; ENSBTAT00000077799; ENSBTAP00000073968; ENSBTAG00000002645.
DR   GeneID; 520254; -.
DR   KEGG; bta:520254; -.
DR   CTD; 80851; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002645; -.
DR   VGNC; VGNC:34569; SH3BP5L.
DR   eggNOG; KOG2008; Eukaryota.
DR   GeneTree; ENSGT00390000018500; -.
DR   HOGENOM; CLU_043711_0_0_1; -.
DR   InParanoid; Q0V8K7; -.
DR   OrthoDB; 566222at2759; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000002645; Expressed in retina and 104 other tissues.
DR   ExpressionAtlas; Q0V8K7; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IBA:GO_Central.
DR   InterPro; IPR007940; SH3BP5.
DR   PANTHER; PTHR19423; PTHR19423; 1.
DR   Pfam; PF05276; SH3BP5; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..385
FT                   /note="SH3 domain-binding protein 5-like"
FT                   /id="PRO_0000317507"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          59..140
FT                   /evidence="ECO:0000255"
FT   COILED          169..272
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        17..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         13
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99LH9"
FT   MOD_RES         343
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT   MOD_RES         350
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT   MOD_RES         358
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT   MOD_RES         362
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7L8J4"
SQ   SEQUENCE   385 AA;  42699 MW;  0A1E67B9DDC53DD2 CRC64;
     MAELRQIPGG RETPQGELRP EVVEDEVPRS PVAEEPGGGG SNSSEAKLSP REEEELDPRI
     QEELEHLNQA SEEINQVELQ LDEARTTYRR ILQESARKLN TQGSHLGSCI EKARPYYEAR
     RLAKEAQQET QKAALRYERA VSMHNAAREM VFVAEQGVMA DKNRLDPTWQ EMLNHATCKV
     NEAEEERLRG EREHQRVTRL CQQAEARVQA LQKTLRRAIG KSRPYFELKA QFSQILEEHK
     AKVTELEQQV AQAKTRYSVA LRNLEQISEQ IHARRRGQPA HTPGQRRSSP VGAEAGPDGG
     EDADSGIIEG AEGGGLEEGV SLGPGAAPDT DTLSLLSLRT VASDLQKCDS VEHLRGLSDH
     TSLDGQELGP RSGGRGGRHQ RSISL