ID   DEOC_CAEEL              Reviewed;         303 AA.
AC   Q19264;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Putative deoxyribose-phosphate aldolase;
DE            Short=DERA;
DE            EC=4.1.2.4;
DE   AltName: Full=2-deoxy-D-ribose 5-phosphate aldolase;
DE   AltName: Full=Phosphodeoxyriboaldolase;
DE            Short=Deoxyriboaldolase;
GN   ORFNames=F09E5.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Catalyzes a reversible aldol reaction between acetaldehyde
CC       and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-
CC       phosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde
CC         3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343,
CC         ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=4.1.2.4;
CC   -!- PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate
CC       degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-
CC       deoxy-alpha-D-ribose 1-phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the DeoC/FbaB aldolase family. DeoC type 2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; FO081044; CCD68756.1; -; Genomic_DNA.
DR   PIR; T16004; T16004.
DR   RefSeq; NP_495009.1; NM_062608.5.
DR   AlphaFoldDB; Q19264; -.
DR   SMR; Q19264; -.
DR   BioGRID; 39256; 33.
DR   STRING; 6239.F09E5.3; -.
DR   EPD; Q19264; -.
DR   PaxDb; Q19264; -.
DR   PeptideAtlas; Q19264; -.
DR   EnsemblMetazoa; F09E5.3.1; F09E5.3.1; WBGene00017283.
DR   GeneID; 173911; -.
DR   KEGG; cel:CELE_F09E5.3; -.
DR   UCSC; F09E5.3.1; c. elegans.
DR   CTD; 173911; -.
DR   WormBase; F09E5.3; CE02610; WBGene00017283; -.
DR   eggNOG; KOG3981; Eukaryota.
DR   GeneTree; ENSGT00390000007878; -.
DR   HOGENOM; CLU_053595_3_0_1; -.
DR   InParanoid; Q19264; -.
DR   OMA; RYSGPDY; -.
DR   OrthoDB; 1349979at2759; -.
DR   PhylomeDB; Q19264; -.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-71336; Pentose phosphate pathway.
DR   UniPathway; UPA00002; UER00468.
DR   PRO; PR:Q19264; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00017283; Expressed in larva and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004139; F:deoxyribose-phosphate aldolase activity; IBA:GO_Central.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IBA:GO_Central.
DR   GO; GO:0009264; P:deoxyribonucleotide catabolic process; IBA:GO_Central.
DR   GO; GO:0046386; P:deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00959; DeoC; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011343; DeoC.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   PANTHER; PTHR10889; PTHR10889; 1.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF001357; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   TIGRFAMs; TIGR00126; deoC; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Schiff base.
FT   CHAIN           1..303
FT                   /note="Putative deoxyribose-phosphate aldolase"
FT                   /id="PRO_0000057312"
FT   ACT_SITE        157
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P0A6L0"
FT   ACT_SITE        220
FT                   /note="Schiff-base intermediate with acetaldehyde"
FT                   /evidence="ECO:0000250|UniProtKB:P0A6L0"
FT   ACT_SITE        256
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P0A6L0"
SQ   SEQUENCE   303 AA;  33087 MW;  5921EA28AB7FEE0E CRC64;
     MATIVPTLFS FVRDTYKGRF DVATFEREVG RDFDNQEIAQ AISKYEQEAK NLRNKDEIRK
     VIQYIDLTTL NGDDTASKVV ALAKRAINPV PTDPSIHCGS VCVYPQRIAD VKKFLASSKL
     NSNITSVAGG FPSGQYHLKS KVLEVELSVA DGATEIDIVI SRASALDEDW KTVHDEVLAC
     KKACGSAHLK TILATGELKT LSNVYRASWA SILAGSDFIK TSTGKESVNA TLEVAYVMCT
     AIKRWHELTG KKVGFKPAGG IKTVDEALSY VALVKDILGD EWLNPHLFRI GASSLLDDCL
     KGL