3BP5L_MOUSE
ID 3BP5L_MOUSE Reviewed; 392 AA.
AC Q99LH9; Q3UMF7; Q8BUC2; Q91YX6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=SH3 domain-binding protein 5-like;
DE Short=SH3BP-5-like;
GN Name=Sh3bp5l; Synonyms=Kiaa1720;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Head, Mammary gland, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-49; SER-357; SER-361
RP AND SER-377, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for
CC RAB11A. {ECO:0000250|UniProtKB:Q7L8J4}.
CC -!- SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000305}.
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DR EMBL; AK086088; BAC39606.1; -; mRNA.
DR EMBL; AK144928; BAE26141.1; -; mRNA.
DR EMBL; AK156171; BAE33611.1; -; mRNA.
DR EMBL; AK172333; BAE42951.1; -; mRNA.
DR EMBL; AL845463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003251; AAH03251.1; -; mRNA.
DR EMBL; BC094418; AAH94418.1; -; mRNA.
DR EMBL; BC013661; AAH13661.1; -; mRNA.
DR CCDS; CCDS24728.1; -.
DR RefSeq; NP_001154810.1; NM_001161338.2.
DR RefSeq; NP_001295097.1; NM_001308168.1.
DR RefSeq; NP_077800.3; NM_024480.5.
DR RefSeq; XP_006534586.1; XM_006534523.1.
DR AlphaFoldDB; Q99LH9; -.
DR SMR; Q99LH9; -.
DR STRING; 10090.ENSMUSP00000112077; -.
DR iPTMnet; Q99LH9; -.
DR PhosphoSitePlus; Q99LH9; -.
DR EPD; Q99LH9; -.
DR jPOST; Q99LH9; -.
DR MaxQB; Q99LH9; -.
DR PaxDb; Q99LH9; -.
DR PeptideAtlas; Q99LH9; -.
DR PRIDE; Q99LH9; -.
DR ProteomicsDB; 296445; -.
DR Antibodypedia; 47904; 23 antibodies from 9 providers.
DR DNASU; 79566; -.
DR Ensembl; ENSMUST00000073128; ENSMUSP00000072872; ENSMUSG00000013646.
DR Ensembl; ENSMUST00000116376; ENSMUSP00000112077; ENSMUSG00000013646.
DR GeneID; 79566; -.
DR KEGG; mmu:79566; -.
DR UCSC; uc007jbe.2; mouse.
DR CTD; 80851; -.
DR MGI; MGI:1933124; Sh3bp5l.
DR VEuPathDB; HostDB:ENSMUSG00000013646; -.
DR eggNOG; KOG2008; Eukaryota.
DR GeneTree; ENSGT00390000018500; -.
DR HOGENOM; CLU_043711_0_0_1; -.
DR InParanoid; Q99LH9; -.
DR OMA; WGQRERL; -.
DR OrthoDB; 566222at2759; -.
DR PhylomeDB; Q99LH9; -.
DR TreeFam; TF105573; -.
DR BioGRID-ORCS; 79566; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Sh3bp5l; mouse.
DR PRO; PR:Q99LH9; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99LH9; protein.
DR Bgee; ENSMUSG00000013646; Expressed in lip and 236 other tissues.
DR Genevisible; Q99LH9; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IBA:GO_Central.
DR InterPro; IPR007940; SH3BP5.
DR PANTHER; PTHR19423; PTHR19423; 1.
DR Pfam; PF05276; SH3BP5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Guanine-nucleotide releasing factor; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..392
FT /note="SH3 domain-binding protein 5-like"
FT /id="PRO_0000317509"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..140
FT /evidence="ECO:0000255"
FT COILED 169..272
FT /evidence="ECO:0000255"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 13
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT MOD_RES 349
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L8J4"
FT MOD_RES 357
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 377
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 148
FT /note="R -> P (in Ref. 1; BAC39606)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="N -> K (in Ref. 1; BAC39606)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="D -> N (in Ref. 1; BAE26141)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 392 AA; 43374 MW; E80AEED11306392C CRC64;
MADLKKAAGG RETPQGELRS EVVEDEGPRS PVAEEPGGSG SNSSETKLSP REEEELDPRI
QEELEHLNQA SEEINQVELQ LDEARTTYRR ILQESARKLN TQGSHLGSCI EKARPYYEAR
RLAKEAQQET QKAALRYERA VSMHNAAREM VFVAEQGVMA DKNRLDPTWQ EMLNHATCKV
NEAEEERLRG EREHQRVTRL CQQAEARVQA LQKTLRRAIG KSRPYFELKA QFSQILEEHK
AKVTELEQQV AQAKTRYSVA LRNLEQISEQ IHARRRGLPP HPLGPRRSSP VGAEAGPEGI
EDGDSGIEGA EGGGLEEGSS LGPGPGPDTD TLSLLSLRTV ASDLQKCDSV EHLRGLSDHA
SLDGQELGAQ SRGRRGSDIG VRGGRHQRSV SL
