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3BP5L_XENTR
ID   3BP5L_XENTR             Reviewed;         373 AA.
AC   A4IH82;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=SH3 domain-binding protein 5-like;
DE            Short=SH3BP-5-like;
GN   Name=sh3bp5l;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as guanine nucleotide exchange factor (GEF) for
CC       rab11a. {ECO:0000250|UniProtKB:Q7L8J4}.
CC   -!- SIMILARITY: Belongs to the SH3BP5 family. {ECO:0000305}.
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DR   EMBL; BC135413; AAI35414.1; -; mRNA.
DR   RefSeq; NP_001093720.1; NM_001100250.1.
DR   RefSeq; XP_012823298.1; XM_012967844.2.
DR   RefSeq; XP_012823299.1; XM_012967845.2.
DR   RefSeq; XP_012823300.1; XM_012967846.2.
DR   AlphaFoldDB; A4IH82; -.
DR   SMR; A4IH82; -.
DR   PaxDb; A4IH82; -.
DR   Ensembl; ENSXETT00000043899; ENSXETP00000043899; ENSXETG00000020349.
DR   GeneID; 100101740; -.
DR   KEGG; xtr:100101740; -.
DR   CTD; 80851; -.
DR   Xenbase; XB-GENE-920564; sh3bp5l.
DR   eggNOG; KOG2008; Eukaryota.
DR   HOGENOM; CLU_043711_0_0_1; -.
DR   InParanoid; A4IH82; -.
DR   OrthoDB; 566222at2759; -.
DR   PhylomeDB; A4IH82; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020349; Expressed in skeletal muscle tissue and 12 other tissues.
DR   ExpressionAtlas; A4IH82; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; IBA:GO_Central.
DR   InterPro; IPR007940; SH3BP5.
DR   PANTHER; PTHR19423; PTHR19423; 2.
DR   Pfam; PF05276; SH3BP5; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..373
FT                   /note="SH3 domain-binding protein 5-like"
FT                   /id="PRO_0000317512"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          55..98
FT                   /evidence="ECO:0000255"
FT   COILED          170..272
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        347..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  41626 MW;  A718CE6CED055A8B CRC64;
     MEGKEGPSCE VRLPTPGAER EGPIHPELGA FGETASNTIK LSESSNDGKK EEIEEELDPR
     IQEELERLNQ ASEEINLLEL QLDEARTAYR RILTESARRL NGLATQLGAC IDKARPYYEA
     RRLAKEAQQD THSAALRYER AVSMHAAARE MVFVAEQGVT ADKNRLDPTW QEMLNHATCK
     VNEAEEERLR SEFEHQRVTR QCHEAEAKVQ TLQKSLKRFI IKSRPYFELK SQLNTILEEH
     KSRVTSLENS VAQAKLRYSG TLRNLEQISE EIHARRTQSS LLSQRAPPLG AEAPPSVKDG
     ETGPPADTVS LLSLQTIASD LQKSDSVEHL RDLTDVTSLD GRETGAVECG GSRERGGDRG
     TGGAFRHHRS VSL
 
 
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