ID   DEOR_ECOL6              Reviewed;         252 AA.
AC   P0ACK6; P06217;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Deoxyribose operon repressor;
GN   Name=deoR; OrderedLocusNames=c0925;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: This protein is one of the repressors that regulate the
CC       expression of deoCABD genes, which encode nucleotide and deoxy
CC       ribonucleotide catabolizing enzymes. It also negatively regulates the
CC       expression of nupG (a transport protein) and tsx (a pore-forming
CC       protein). The inducer is deoxyribose-5-phosphate (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooctamer. {ECO:0000250}.
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DR   EMBL; AE014075; AAN79398.1; -; Genomic_DNA.
DR   RefSeq; WP_000450121.1; NC_004431.1.
DR   AlphaFoldDB; P0ACK6; -.
DR   SMR; P0ACK6; -.
DR   STRING; 199310.c0925; -.
DR   EnsemblBacteria; AAN79398; AAN79398; c0925.
DR   GeneID; 58460679; -.
DR   KEGG; ecc:c0925; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_4_0_6; -.
DR   OMA; CFHFHEV; -.
DR   BioCyc; ECOL199310:C0925-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..252
FT                   /note="Deoxyribose operon repressor"
FT                   /id="PRO_0000050246"
FT   DOMAIN          5..57
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   252 AA;  28548 MW;  69D20CEC86080233 CRC64;
     METRREERIG QLLQELKRSD KLHLKDAAAL LGVSEMTIRR DLNNHSAPVV LLGGYIVLEP
     RSASHYLLSD QKSRLVEEKR RAAKLAATLV EPDQTLFFDC GTTTPWIIEA IDNEIPFTAV
     CYSLNTFLAL KEKPHCRAFL CGGEFHASNA IFKPIDFQQT LNNFCPDIAF YSAAGVHVSK
     GATCFNLEEL PVKHWAMSMA QKHVLVVDHS KFGKVRPARM GDLKRFDIVV SDCCPEDEYV
     KYAQTQRIKL MY