DEOR_ECOLI
ID DEOR_ECOLI Reviewed; 252 AA.
AC P0ACK5; P06217;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Deoxyribose operon repressor;
GN Name=deoR; Synonyms=nucR; OrderedLocusNames=b0840, JW0824;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2994018; DOI=10.1093/nar/13.16.5927;
RA Valentin-Hansen P., Hoejrup P., Short S.;
RT "The primary structure of the DeoR repressor from Escherichia coli K-12.";
RL Nucleic Acids Res. 13:5927-5936(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP SUBUNIT.
RX PubMed=2653814; DOI=10.1002/j.1460-2075.1989.tb03380.x;
RA Mortensen L., Dandanell G., Hammer K.;
RT "Purification and characterization of the deoR repressor of Escherichia
RT coli.";
RL EMBO J. 8:325-331(1989).
CC -!- FUNCTION: This protein is one of the repressors that regulate the
CC expression of deoCABD genes, which encode nucleotide and deoxy
CC ribonucleotide catabolizing enzymes. It also negatively regulates the
CC expression of nupG (a transport protein) and tsx (a pore-forming
CC protein). The inducer is deoxyribose-5-phosphate.
CC -!- SUBUNIT: Homooctamer. {ECO:0000305|PubMed:2653814}.
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DR EMBL; X02837; CAA26598.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73927.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35543.1; -; Genomic_DNA.
DR PIR; A24076; RPECDO.
DR RefSeq; NP_415361.1; NC_000913.3.
DR RefSeq; WP_000450121.1; NZ_STEB01000019.1.
DR PDB; 7L6L; X-ray; 1.75 A; A/B/C/D/E/F=70-252.
DR PDBsum; 7L6L; -.
DR AlphaFoldDB; P0ACK5; -.
DR SMR; P0ACK5; -.
DR BioGRID; 4262826; 9.
DR DIP; DIP-9430N; -.
DR IntAct; P0ACK5; 4.
DR STRING; 511145.b0840; -.
DR jPOST; P0ACK5; -.
DR PaxDb; P0ACK5; -.
DR PRIDE; P0ACK5; -.
DR EnsemblBacteria; AAC73927; AAC73927; b0840.
DR EnsemblBacteria; BAA35543; BAA35543; BAA35543.
DR GeneID; 58460679; -.
DR GeneID; 945453; -.
DR KEGG; ecj:JW0824; -.
DR KEGG; eco:b0840; -.
DR PATRIC; fig|1411691.4.peg.1438; -.
DR EchoBASE; EB0219; -.
DR eggNOG; COG1349; Bacteria.
DR HOGENOM; CLU_060699_4_0_6; -.
DR OMA; CFHFHEV; -.
DR PhylomeDB; P0ACK5; -.
DR BioCyc; EcoCyc:PD01196; -.
DR PRO; PR:P0ACK5; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:2000143; P:negative regulation of DNA-templated transcription, initiation; IMP:EcoCyc.
DR InterPro; IPR014036; DeoR_C.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR Pfam; PF00455; DeoRC; 1.
DR Pfam; PF08220; HTH_DeoR; 1.
DR SMART; SM00420; HTH_DEOR; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR PROSITE; PS00894; HTH_DEOR_1; 1.
DR PROSITE; PS51000; HTH_DEOR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..252
FT /note="Deoxyribose operon repressor"
FT /id="PRO_0000050244"
FT DOMAIN 5..57
FT /note="HTH deoR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT DNA_BIND 22..41
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT HELIX 76..87
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 95..98
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 100..103
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 104..110
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 117..121
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 124..131
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 136..140
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 148..150
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 151..153
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 161..163
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 167..171
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 174..177
FT /evidence="ECO:0007829|PDB:7L6L"
FT TURN 178..180
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 181..185
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 190..199
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 201..206
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 209..211
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 217..221
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 223..225
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:7L6L"
FT HELIX 237..246
FT /evidence="ECO:0007829|PDB:7L6L"
FT STRAND 249..251
FT /evidence="ECO:0007829|PDB:7L6L"
SQ SEQUENCE 252 AA; 28548 MW; 69D20CEC86080233 CRC64;
METRREERIG QLLQELKRSD KLHLKDAAAL LGVSEMTIRR DLNNHSAPVV LLGGYIVLEP
RSASHYLLSD QKSRLVEEKR RAAKLAATLV EPDQTLFFDC GTTTPWIIEA IDNEIPFTAV
CYSLNTFLAL KEKPHCRAFL CGGEFHASNA IFKPIDFQQT LNNFCPDIAF YSAAGVHVSK
GATCFNLEEL PVKHWAMSMA QKHVLVVDHS KFGKVRPARM GDLKRFDIVV SDCCPEDEYV
KYAQTQRIKL MY
