ID   DEP1A_DANRE             Reviewed;         800 AA.
AC   Q803Q4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DEP domain-containing protein 1A;
GN   Name=depdc1a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC044382; AAH44382.1; -; mRNA.
DR   RefSeq; NP_942573.1; NM_198872.1.
DR   AlphaFoldDB; Q803Q4; -.
DR   SMR; Q803Q4; -.
DR   STRING; 7955.ENSDARP00000049675; -.
DR   PaxDb; Q803Q4; -.
DR   GeneID; 100003959; -.
DR   KEGG; dre:100003959; -.
DR   CTD; 76131; -.
DR   ZFIN; ZDB-GENE-030131-9827; depdc1a.
DR   eggNOG; ENOG502QR00; Eukaryota.
DR   InParanoid; Q803Q4; -.
DR   OrthoDB; 413007at2759; -.
DR   PhylomeDB; Q803Q4; -.
DR   PRO; PR:Q803Q4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..800
FT                   /note="DEP domain-containing protein 1A"
FT                   /id="PRO_0000284788"
FT   DOMAIN          24..108
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   DOMAIN          281..321
FT                   /note="Rho-GAP"
FT   REGION          147..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   800 AA;  90690 MW;  7B977183CF94CFD2 CRC64;
     MSSHIVTPGP YRATKLWNEV TKLFRAGMPL KKHRQHFRVY TNCFTASTAV DWLHELLKNN
     SNFGPDVTRQ QTVQLLKKFL KNHVIEDVKG RWGMEDLEDN SQLYRFPSTS PLKPIPNRPT
     VMRRKSLSMM DRESFFKFRG SKKFDKETLE NVDPETQESP VGSSSGETER SRELTEDDIH
     VIWKNVTLTH LQKLVGSASL EGVLDPAKVN PQFIVYNMTK VNKHGVVSLE DKTEDLPHWA
     LSAMKCLANW PKYDSDQPTY LGFERDVFKT VSDYFYSLPQ PLLTYQYYEL FVNILVMCGY
     ITTPKSQPGK RKNQEEPNCP QPAKNPYVNP ANLFRSTEYL LLSLIRKEAI DEADSPMKEV
     FSSKTETKLD TRRVFRGRRV SDGDRLDGSY LDVSQAHKTD VPYGRLRPRS CSLEGNINNC
     AKSRLFRSSE SLESCSSDKS NPETDSPLEP NLQSSLVSIN TSGSSVSSQL SADLRRNNSR
     PARARPRSIG NLFDIEENRE MSASSFSVHA PVAEITMRPD STSSVGFRGL GLSSLHGSCV
     DVRTGPSFSR RCQSSLDLSK PAPARPPSAL LTHQPEQSLL QPSLEQVAVE ALQLCTLLLP
     PASRRKLQLL LRMISRMSQN VDMPRLHDVI GTRTLLVQTF SRCVLSCEEV DDLDELLATR
     LLSFLMDHHQ EVLQVPVYLR NAVEDHINYL KSLSSCPGSA GPIPSYSFCR QISCQEFEQQ
     KLSVSQSALA DLLENIIKDK SMSVKEKKKK IKLFQKEYPD IYSRRFPTTE SETQLFADKP
     KIKPPMLLSI KKAKTFSIRN