ID   DEP1A_XENLA             Reviewed;         806 AA.
AC   Q6ING4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DEP domain-containing protein 1A;
GN   Name=depdc1a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072317; AAH72317.1; -; mRNA.
DR   RefSeq; NP_001085413.1; NM_001091944.1.
DR   AlphaFoldDB; Q6ING4; -.
DR   SMR; Q6ING4; -.
DR   MaxQB; Q6ING4; -.
DR   PRIDE; Q6ING4; -.
DR   DNASU; 443839; -.
DR   GeneID; 443839; -.
DR   KEGG; xla:443839; -.
DR   CTD; 443839; -.
DR   Xenbase; XB-GENE-6465995; depdc1.L.
DR   OrthoDB; 413007at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 443839; Expressed in blastula and 14 other tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..806
FT                   /note="DEP domain-containing protein 1A"
FT                   /id="PRO_0000284789"
FT   DOMAIN          24..108
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   DOMAIN          279..319
FT                   /note="Rho-GAP"
FT   REGION          142..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   806 AA;  92609 MW;  A9C932248F60BC35 CRC64;
     MDSRIITPGP YRATKLWNEV TKHFRAAMPL RKHRQHFKAY GNCFTASEAI DWLHQLLKTN
     SNFGSEVTRQ QTIQLLRKFL KNHVIEDLKG RWGTEELEDN NSLYRFPSTS PVKTIPSRPP
     LWKRSSLENV FKEKEHLFKM PQFSKKTPKR RASVDSKEEQ ENEDLMEDQR NDDDFPKQLS
     SKDIEDIWGN ITMIHLQKIL GLPSLEEVLN PAQIKPNYIR YNMTNTSKHG VVVLQDKTDD
     LPHWVLSAMK CLANWPKNND MSQATYIGFE RDVFRTVADY FLNLPEPLLT FEFYELFVNI
     LVVCGYITVP NSHNGKHRFH NKTRDPAPAK KQHLNDEQFF KSTECLLLSL VRKVPNEEED
     DVEHSFGEIA RDNKDHIPRD VFAKKNHLYG SFSRRASRGT IGGSCQNLST SRKETGVTRK
     VRVRSCSLEG IADSVSTDVR DCQSNILQPS SQKPEFSVVK ERPITFGNQA ESVTGLNASE
     HKLHYRTSDG GYSQTSEKLA RSVSVGDCLE SRTSKNAPVA EITIKPLKSK QTRMQKRFSP
     TDNEPTDLDF TVTKRLCQST MELSHSSFPS TSSLLPPTTS PNSTGSESLL QPHLEKVAIE
     ALQLCCLLLP PANRRKLQLL MRMISRMSQN VDMPRLHDAM GTRSLMIQTF SRCVLCCAEE
     VDLDELLASR LVSFLMDHHQ DILQVPCYLQ TAVQDHVQYL QRPRVKQGTV PEYYFCKQIS
     AQEFEEQRLA TSQAAIMELL ENIVRDKALA VKDKKKKLKQ FQKQYPDIYQ SRFPTTESEA
     KLFGDKPTIK QPMLMLKKPK FKSLRY