ID   DEP1B_CHICK             Reviewed;         529 AA.
AC   Q5ZLD2;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DEP domain-containing protein 1B;
GN   Name=DEPDC1B; ORFNames=RCJMB04_6k16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
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DR   EMBL; AJ719802; CAG31461.1; -; mRNA.
DR   RefSeq; NP_001006576.1; NM_001006576.1.
DR   AlphaFoldDB; Q5ZLD2; -.
DR   SMR; Q5ZLD2; -.
DR   STRING; 9031.ENSGALP00000023706; -.
DR   PaxDb; Q5ZLD2; -.
DR   GeneID; 427152; -.
DR   KEGG; gga:427152; -.
DR   CTD; 55789; -.
DR   VEuPathDB; HostDB:geneid_427152; -.
DR   eggNOG; ENOG502QR00; Eukaryota.
DR   InParanoid; Q5ZLD2; -.
DR   OrthoDB; 413007at2759; -.
DR   PhylomeDB; Q5ZLD2; -.
DR   PRO; PR:Q5ZLD2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..529
FT                   /note="DEP domain-containing protein 1B"
FT                   /id="PRO_0000284793"
FT   DOMAIN          24..108
FT                   /note="DEP"
FT   DOMAIN          192..393
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
SQ   SEQUENCE   529 AA;  61114 MW;  3A4330DFCF5296C4 CRC64;
     MEPGLVGPGP YRATRLWNEI IELFRAGMPL RKHRCRFKSY ERCFKASEAV DCLHELLGSN
     QNFGPEVTRS QTVKLLKKFL KNHVIEDIKG RWGKEDFQDD GHLYRFPPSS PLKPYPKKPS
     FGKEVIKFPD WDDPKAGTSQ EHIPVKSIMM NSETWYKRHS IAIGEVPACK LVFRRELTQE
     NIEEIWKSMT LARLQKVLGL DCLDEVIDTK LVNSKHIVQN AYNVNKQGIV TLEDKSKDLP
     HWILSAMKCL ANWPICSDLK QPTYSGFERD VFKTIVDYFG QMKEPLLTFN FFDVFVSVLG
     LLQKHNEAIE ALQISCLLLP PESRRKLQLL VRMMARISFN KDLPPLSESV RTRVLMVQAF
     SRCILCSKDE MDLDELLAAK LVSFLMDNYQ EILSVPSSLK SSIEEHVVHV QRVQIKYAGA
     DTDAAFPAPS FCHQISTDEF EYQRATGSQE PLAALLEEIA TNKEISVKDK KKKLKQFQKS
     YPEVYRVRFP TPETEAVLFP EKSKQKPPLL MWALRKPFQP FHRTRSFRM