ID   DEP1B_MACFA             Reviewed;         529 AA.
AC   Q4R623;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DEP domain-containing protein 1B;
GN   Name=DEPDC1B; ORFNames=QtsA-19314;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AB169367; BAE01452.1; -; mRNA.
DR   RefSeq; NP_001274660.1; NM_001287731.1.
DR   AlphaFoldDB; Q4R623; -.
DR   SMR; Q4R623; -.
DR   STRING; 9541.XP_005557022.1; -.
DR   Ensembl; ENSMFAT00000069624; ENSMFAP00000019076; ENSMFAG00000032556.
DR   GeneID; 102140925; -.
DR   CTD; 55789; -.
DR   VEuPathDB; HostDB:ENSMFAG00000032556; -.
DR   eggNOG; ENOG502QR00; Eukaryota.
DR   GeneTree; ENSGT00950000182976; -.
DR   OMA; ELPHWIL; -.
DR   OrthoDB; 413007at2759; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   Bgee; ENSMFAG00000032556; Expressed in bone marrow and 4 other tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..529
FT                   /note="DEP domain-containing protein 1B"
FT                   /id="PRO_0000284791"
FT   DOMAIN          24..108
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   DOMAIN          201..393
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   MOD_RES         160
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WUY9"
FT   MOD_RES         436
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WUY9"
SQ   SEQUENCE   529 AA;  61892 MW;  1F5CD6FD259DC36F CRC64;
     MEHRIVGPGP YRATRLWNET VELFRAKMPL RKHRCRFKSY EHCFTAAEAV DWLHELLRCS
     QNFGPEVTRK QTVQLLKKFL KNHVIEDIKG KWGQEDFEDN RHLYRFPPSS PLKPYPKKPP
     YQKDVIKFPE WNDPPPGTSQ ENIPVRPVVM NSEMWYKRHS IAIGEVPACR LVHRRQLTEA
     NVEEIWKSMT LSYLQKILGL DSLEEVLDIK LVNSKFIIHN VYSVSKQGVV ILDDKSKELP
     HWVLSAMKCL ANWPNCSDLK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
     LLQKEKVAVE AFQICCLLLP PENRRKLQLL MRMMARICLN KEMPPLCDGF GTRTLMVQTF
     SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLDLQ TSIEERVAHL RRVQIKYPGA
     DMDITLSAPS FCRQISPEEF EYQRSYGSQE PLAALLEEVI TDAKLSSKEK KKKLKQFQKS
     YPEVYQERFP TPESEALLFP EKPKPKPQLL MWALKKPFQP FQRTRSFRM