DEP1B_MOUSE
ID DEP1B_MOUSE Reviewed; 529 AA.
AC Q8BH88; Q810T1; Q8BZ67;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=DEP domain-containing protein 1B;
GN Name=Depdc1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, Cerebellum, Colon, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-529.
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK036550; BAC29473.1; -; mRNA.
DR EMBL; AK043283; BAC31514.1; -; mRNA.
DR EMBL; AK077676; BAC36949.1; -; mRNA.
DR EMBL; AK083480; BAC38932.1; -; mRNA.
DR EMBL; BC048246; AAH48246.1; -; mRNA.
DR CCDS; CCDS26762.1; -.
DR RefSeq; NP_848798.1; NM_178683.4.
DR AlphaFoldDB; Q8BH88; -.
DR SMR; Q8BH88; -.
DR STRING; 10090.ENSMUSP00000059291; -.
DR iPTMnet; Q8BH88; -.
DR PhosphoSitePlus; Q8BH88; -.
DR EPD; Q8BH88; -.
DR jPOST; Q8BH88; -.
DR MaxQB; Q8BH88; -.
DR PaxDb; Q8BH88; -.
DR PRIDE; Q8BH88; -.
DR ProteomicsDB; 279625; -.
DR Antibodypedia; 23636; 175 antibodies from 23 providers.
DR DNASU; 218581; -.
DR Ensembl; ENSMUST00000051594; ENSMUSP00000059291; ENSMUSG00000021697.
DR Ensembl; ENSMUST00000163307; ENSMUSP00000131707; ENSMUSG00000021697.
DR GeneID; 218581; -.
DR KEGG; mmu:218581; -.
DR UCSC; uc007rvc.1; mouse.
DR CTD; 55789; -.
DR MGI; MGI:2145425; Depdc1b.
DR VEuPathDB; HostDB:ENSMUSG00000021697; -.
DR eggNOG; ENOG502QR00; Eukaryota.
DR GeneTree; ENSGT00950000182976; -.
DR InParanoid; Q8BH88; -.
DR OMA; ELPHWIL; -.
DR OrthoDB; 413007at2759; -.
DR PhylomeDB; Q8BH88; -.
DR TreeFam; TF328365; -.
DR Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR Reactome; R-MMU-9013026; RHOB GTPase cycle.
DR Reactome; R-MMU-9013106; RHOC GTPase cycle.
DR Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR Reactome; R-MMU-9013404; RAC2 GTPase cycle.
DR Reactome; R-MMU-9013405; RHOD GTPase cycle.
DR Reactome; R-MMU-9013406; RHOQ GTPase cycle.
DR Reactome; R-MMU-9013408; RHOG GTPase cycle.
DR Reactome; R-MMU-9013409; RHOJ GTPase cycle.
DR Reactome; R-MMU-9013420; RHOU GTPase cycle.
DR Reactome; R-MMU-9013423; RAC3 GTPase cycle.
DR Reactome; R-MMU-9013424; RHOV GTPase cycle.
DR Reactome; R-MMU-9035034; RHOF GTPase cycle.
DR Reactome; R-MMU-9696264; RND3 GTPase cycle.
DR Reactome; R-MMU-9696270; RND2 GTPase cycle.
DR Reactome; R-MMU-9696273; RND1 GTPase cycle.
DR BioGRID-ORCS; 218581; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Depdc1b; mouse.
DR PRO; PR:Q8BH88; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8BH88; protein.
DR Bgee; ENSMUSG00000021697; Expressed in manus and 125 other tissues.
DR ExpressionAtlas; Q8BH88; baseline and differential.
DR Genevisible; Q8BH88; MM.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; ISO:MGI.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISO:MGI.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW GTPase activation; Phosphoprotein; Reference proteome.
FT CHAIN 1..529
FT /note="DEP domain-containing protein 1B"
FT /id="PRO_0000284792"
FT DOMAIN 24..108
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT DOMAIN 201..393
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUY9"
FT MOD_RES 436
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUY9"
FT CONFLICT 28
FT /note="M -> I (in Ref. 1; BAC29473)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="A -> V (in Ref. 2; AAH48246)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 529 AA; 61908 MW; 402E14BCC405D1A7 CRC64;
MEHRVVGPGP YRATRLWNET VELFRARMPL RRHRCRFKSY EHCFTASEAV DWLHELLRNS
QNFGPEVTRK QTVQLLGKFL KNHVIEDIKG KWGQEDFEDN RHLYRFPPSS PLKPYPKKPL
YQRDVIKFPE WNDPPPGTSQ ENIPVRPIVM NSEMWFKRHS IAIGEVPACR LVHRRQLTEA
NVEEIWKSTT LSYLQKILGL DSLEEVLNTK LVSSKFIIHN VYSVSKQGVV ILDDKSKELP
HWVLSAMKCL ANWPNCTDWK QPMYLGFEKD VFKTIADYYG HLKEPLLTFH LFDAFVSVLG
LLPKEKTAIE AFQLCCLLLP PENRRKLQLL MRMMARICLN KEMPPLSDGF GTRTLMVQTF
SRCILCSKDE VDLDELLAAR LVTFLMDNYQ EILKVPLALQ TSIEERVAHL RRVQIKYPGA
DMDITLSAPS FCRQISPEEF EYQRAYGSQE PLAALLEEVI ADDKLSSKEK KKKLKQFQKS
YPEVYQERFP TPESEALLFP EKPKAKPQLF MWALRKPFQP FQRTRSFRM
