ID   DEP6_ALTBR              Reviewed;         646 AA.
AC   D2E9X1;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Depudecin biosynthesis cluster-specific transcription activator DEP6 {ECO:0000303|PubMed:19737099};
DE   AltName: Full=Depudecin biosynthesis cluster protein 6 {ECO:0000303|PubMed:19737099};
GN   Name=DEP6 {ECO:0000303|PubMed:19737099};
OS   Alternaria brassicicola (Dark leaf spot agent).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC   Alternaria sect. Brassicicola.
OX   NCBI_TaxID=29001;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, AND FUNCTION.
RC   STRAIN=MUCL 202097;
RX   PubMed=19737099; DOI=10.1094/mpmi-22-10-1258;
RA   Wight W.D., Kim K.-H., Lawrence C.B., Walton J.D.;
RT   "Biosynthesis and role in virulence of the histone deacetylase inhibitor
RT   depudecin from Alternaria brassicicola.";
RL   Mol. Plant Microbe Interact. 22:1258-1267(2009).
CC   -!- FUNCTION: Transcription factor that positively regulates the expression
CC       of the gene cluster that mediates the biosynthesis of depudecin, a
CC       highly oxidized eleven-carbon linear polyketide that acts as a histone
CC       deacetylase (HDAC) inhibitor and makes a small contribution to
CC       pathogenesis (PubMed:19737099). {ECO:0000269|PubMed:19737099}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DISRUPTION PHENOTYPE: Affects the expression of all the depudecin
CC       cluster genes and impairs the production of depudecin
CC       (PubMed:19737099). {ECO:0000269|PubMed:19737099}.
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DR   EMBL; FJ977165; ACZ57549.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2E9X1; -.
DR   SMR; D2E9X1; -.
DR   PHI-base; PHI:2380; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..646
FT                   /note="Depudecin biosynthesis cluster-specific
FT                   transcription activator DEP6"
FT                   /id="PRO_0000441945"
FT   DNA_BIND        16..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          76..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  72538 MW;  EB48458C8DF206C4 CRC64;
     MRSSSAGTPF TAQYACEICR ERKVRCDRAL PKCRRCDRLN QPCSYNQAHQ RRTRDEQLKQ
     LQERLAKTEA QLAMNTTAAP LSVRSQSRSE GTELASSTRW IGTPDSFTPN SCSRRSSQYQ
     LPTTSTSQSQ LGSVLGTTAA NTPMDLDNIR GMSATSGMST NGSSLFDSDL FTSFTEGADS
     NMTFAWTNQP LMALEPLDNM LLNRPQSAPP NGSEEDLSPT DLSLLHNHYF ESVYFSFPFI
     NRDRFTAEKT GSRSPATTAL VYAVALAGCT RSLQDHNRQS TCYGLARNYA ERCEQEDHLN
     DLNFLQALLL IGRFEAMNRK LERSGLTLGR AAMLCKLLKL HQMDKSEHSQ GMQNRETQSG
     PRLALPHTKD PVLLEERRRT FWGLYILQSY VRTRTGWEFQ LEDTKNLQIN LPSPGLLRSD
     LEPLKMPSLL NISTEPAPEI TSYAGCVLMV ELALRCFDNG QKRDTPGFWD DYCALVKKTD
     DLFKTLKRHL NATSIREDPV AFSLYLNLRA TEIFSHDSAI TKNEEQGLPP LMVAESQRRA
     TTAAFQICSA VGLNLPSPWK ADSDIIMLQA IFIAWPLTMA LKALYRELVR GGIRETVNGV
     VASIRLLFAA LDHIEESDGH WHQCVTNVEA KLQEWDEKNS FDSLAL