ID   DEP6_FUSLA              Reviewed;         611 AA.
AC   A0A0M9ER64;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 2.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Depudecin biosynthesis cluster-specific transcription activator DEP6 {ECO:0000303|PubMed:19737099};
DE   AltName: Full=Depudecin biosynthesis cluster protein 6 {ECO:0000303|PubMed:19737099};
GN   Name=DEP6 {ECO:0000303|PubMed:19737099}; ORFNames=FLAG1_09231;
OS   Fusarium langsethiae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=179993;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fl201059;
RA   Lysoe E., Divon H.H., Terzi V., Orru L., Lamontanara A., Kolseth A.-K.,
RA   Frandsen R.J., Nielsen K., Thrane U.;
RT   "The draft genome sequence of Fusarium langsethiae, a T-2/HT-2 mycotoxin
RT   producer.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=19737099; DOI=10.1094/mpmi-22-10-1258;
RA   Wight W.D., Kim K.-H., Lawrence C.B., Walton J.D.;
RT   "Biosynthesis and role in virulence of the histone deacetylase inhibitor
RT   depudecin from Alternaria brassicicola.";
RL   Mol. Plant Microbe Interact. 22:1258-1267(2009).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=28460114; DOI=10.1093/molbev/msx145;
RA   Reynolds H., Slot J.C., Divon H.H., Lysoee E., Proctor R.H., Brown D.W.;
RT   "Differential retention of gene functions in a secondary metabolite
RT   cluster.";
RL   Mol. Biol. Evol. 34:2002-2015(2017).
CC   -!- FUNCTION: Transcription factor that positively regulates the expression
CC       of the gene cluster that mediates the biosynthesis of depudecin, a
CC       highly oxidized eleven-carbon linear polyketide that acts as a histone
CC       deacetylase (HDAC) inhibitor and makes a small contribution to
CC       pathogenesis (PubMed:19737099, PubMed:28460114).
CC       {ECO:0000269|PubMed:19737099, ECO:0000305|PubMed:28460114}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=KPA37940.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; JXCE01000338; KPA37940.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; A0A0M9ER64; -.
DR   SMR; A0A0M9ER64; -.
DR   EnsemblFungi; KPA37940; KPA37940; FLAG1_09231.
DR   OrthoDB; 455010at2759; -.
DR   Proteomes; UP000037904; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..611
FT                   /note="Depudecin biosynthesis cluster-specific
FT                   transcription activator DEP6"
FT                   /id="PRO_0000441946"
FT   DNA_BIND        17..44
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          76..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   611 AA;  67814 MW;  F4AB3E113A9E9AA8 CRC64;
     MIRQFSAGSS FTARHACEIC RQRKVRCDRA LPRCRRCERL NQACVYSPIS QRRTRDEQLQ
     ELQERLAKTE AQLALDAPRG PASSMSSQSR SDSAAPAASR VPSVSASVPN SAATNPMDMV
     GTRSSNTSMD LPVNTSPMLD IDLFTAGADS NMALDWNPYL TALEPLDNLL PNRLSPRSLP
     QNGREEDISL AELNALHNYY FESVYFSFPF LNRDRFAGES TGNGPAINAL IYSVALAGCT
     HSSPQHTKVS IYYTLARNYA EKCERDGQLN DLNFLQALLF IGRFEAMEGK VESSWMTLGR
     AAMLARLLRL PQMDRLEEST ESQDGSGLSL LETTDPALLE ERRRTFWALY ILQSYIKTRT
     GWQCMLGDIK TFQINLPSPG LLRSDLTPLK MPFISEIGTE PCPEVSSYAG CVLMVDLALR
     CLDHAQGHGA TNFWDGYCAL VKNTDELFGM LKQHLNATSI RKDPVAFSLY LNLRATEIFS
     HESAIARSKE QGLPPLMTAE SQRRATAAAF QISTAVRLNL PSPWKVDSDI IMLQAIFIAW
     PLAMALKAFY RELEHGGSRD SVNGVVTSSR LLFAALGHIE ESGGHWHQSV AHVEAKLQEL
     DEKNGFNSLA L