DEPD4_HUMAN
ID DEPD4_HUMAN Reviewed; 294 AA.
AC Q8N2C3; Q496C8; Q96BW0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=DEP domain-containing protein 4;
GN Name=DEPDC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1).
RC TISSUE=Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N2C3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N2C3-2; Sequence=VSP_024646, VSP_024647;
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DR EMBL; AK090824; BAC03525.1; -; mRNA.
DR EMBL; BC015117; AAH15117.1; -; mRNA.
DR EMBL; BC100929; AAI00930.1; -; mRNA.
DR CCDS; CCDS9075.1; -. [Q8N2C3-1]
DR RefSeq; NP_001306239.1; NM_001319310.1.
DR RefSeq; NP_689530.1; NM_152317.3. [Q8N2C3-1]
DR AlphaFoldDB; Q8N2C3; -.
DR STRING; 9606.ENSP00000396234; -.
DR iPTMnet; Q8N2C3; -.
DR PhosphoSitePlus; Q8N2C3; -.
DR BioMuta; DEPDC4; -.
DR DMDM; 74728709; -.
DR PaxDb; Q8N2C3; -.
DR PeptideAtlas; Q8N2C3; -.
DR PRIDE; Q8N2C3; -.
DR Antibodypedia; 51125; 23 antibodies from 16 providers.
DR DNASU; 120863; -.
DR Ensembl; ENST00000299185.12; ENSP00000299185.8; ENSG00000166153.17. [Q8N2C3-2]
DR Ensembl; ENST00000378244.6; ENSP00000367490.2; ENSG00000166153.17. [Q8N2C3-1]
DR Ensembl; ENST00000416321.5; ENSP00000396234.1; ENSG00000166153.17. [Q8N2C3-1]
DR Ensembl; ENST00000549341.1; ENSP00000447392.1; ENSG00000166153.17. [Q8N2C3-2]
DR GeneID; 120863; -.
DR KEGG; hsa:120863; -.
DR UCSC; uc001thh.2; human. [Q8N2C3-1]
DR CTD; 120863; -.
DR DisGeNET; 120863; -.
DR GeneCards; DEPDC4; -.
DR HGNC; HGNC:22952; DEPDC4.
DR HPA; ENSG00000166153; Tissue enhanced (testis).
DR neXtProt; NX_Q8N2C3; -.
DR OpenTargets; ENSG00000166153; -.
DR PharmGKB; PA134981607; -.
DR VEuPathDB; HostDB:ENSG00000166153; -.
DR eggNOG; ENOG502QW4D; Eukaryota.
DR GeneTree; ENSGT00950000182976; -.
DR HOGENOM; CLU_3092752_0_0_1; -.
DR InParanoid; Q8N2C3; -.
DR OMA; YEMISNH; -.
DR OrthoDB; 1481944at2759; -.
DR PhylomeDB; Q8N2C3; -.
DR PathwayCommons; Q8N2C3; -.
DR BioGRID-ORCS; 120863; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; DEPDC4; human.
DR GenomeRNAi; 120863; -.
DR Pharos; Q8N2C3; Tdark.
DR PRO; PR:Q8N2C3; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N2C3; protein.
DR Bgee; ENSG00000166153; Expressed in ventricular zone and 91 other tissues.
DR ExpressionAtlas; Q8N2C3; baseline and differential.
DR Genevisible; Q8N2C3; HS.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00610; DEP; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..294
FT /note="DEP domain-containing protein 4"
FT /id="PRO_0000284783"
FT DOMAIN 71..162
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT VAR_SEQ 53..57
FT /note="GCSGP -> DQDMK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024646"
FT VAR_SEQ 58..294
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024647"
FT VARIANT 122
FT /note="H -> R (in dbSNP:rs7307415)"
FT /id="VAR_031815"
FT CONFLICT 34
FT /note="L -> G (in Ref. 2; AAH15117)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 294 AA; 33694 MW; 0073B8E83402EA43 CRC64;
MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTGCSGPFQA
TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV LSHLMQNTCL SSNDISCLKG
VHLCQVLMNH KVFEPVGMKK LFKKEKELEF EDSNISLYRF LGNKSSYDCC KRQKDAENEF
NETLRPGYEM ISNPLAQEIG EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT
LLCLLQLIHL PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK
