DEPD7_HUMAN
ID DEPD7_HUMAN Reviewed; 511 AA.
AC Q96QD5; G5E941; Q8N602; Q8NCU9; Q9UGK5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=DEP domain-containing protein 7;
DE AltName: Full=Protein TR2/D15;
GN Name=DEPDC7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=10568747; DOI=10.1101/gr.9.11.1074;
RA Gawin B., Niederfuehr A., Schumacher N., Hummerich H., Little P.F.R.,
RA Gessler M.;
RT "A 7.5 Mb sequence-ready PAC contig and gene expression map of human
RT chromosome 11p13-p14.1.";
RL Genome Res. 9:1074-1086(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RA Guo J.H., Yu L.;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-464.
RC TISSUE=Bone marrow;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96QD5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96QD5-2; Sequence=VSP_047180;
CC -!- TISSUE SPECIFICITY: Expressed in liver. {ECO:0000269|PubMed:10568747}.
CC -!- SIMILARITY: Belongs to the DEPDC7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM22871.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ245600; CAB53247.1; -; mRNA.
DR EMBL; AF447588; AAM22871.1; ALT_INIT; mRNA.
DR EMBL; AC107939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121926; CAC48255.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68213.1; -; Genomic_DNA.
DR EMBL; BC030970; AAH30970.1; -; mRNA.
DR CCDS; CCDS41632.1; -. [Q96QD5-1]
DR CCDS; CCDS41633.1; -. [Q96QD5-2]
DR RefSeq; NP_001070710.1; NM_001077242.1. [Q96QD5-1]
DR RefSeq; NP_631899.2; NM_139160.2. [Q96QD5-2]
DR AlphaFoldDB; Q96QD5; -.
DR SMR; Q96QD5; -.
DR BioGRID; 124854; 17.
DR IntAct; Q96QD5; 10.
DR MINT; Q96QD5; -.
DR STRING; 9606.ENSP00000241051; -.
DR iPTMnet; Q96QD5; -.
DR PhosphoSitePlus; Q96QD5; -.
DR BioMuta; DEPDC7; -.
DR DMDM; 74717175; -.
DR jPOST; Q96QD5; -.
DR MassIVE; Q96QD5; -.
DR MaxQB; Q96QD5; -.
DR PaxDb; Q96QD5; -.
DR PeptideAtlas; Q96QD5; -.
DR PRIDE; Q96QD5; -.
DR ProteomicsDB; 33821; -.
DR ProteomicsDB; 77853; -. [Q96QD5-1]
DR ProteomicsDB; 77854; -. [Q96QD5-2]
DR TopDownProteomics; Q96QD5-1; -. [Q96QD5-1]
DR Antibodypedia; 6356; 158 antibodies from 21 providers.
DR DNASU; 91614; -.
DR Ensembl; ENST00000241051.8; ENSP00000241051.3; ENSG00000121690.11. [Q96QD5-1]
DR Ensembl; ENST00000311388.7; ENSP00000308971.3; ENSG00000121690.11. [Q96QD5-2]
DR GeneID; 91614; -.
DR KEGG; hsa:91614; -.
DR MANE-Select; ENST00000241051.8; ENSP00000241051.3; NM_001077242.2; NP_001070710.1.
DR UCSC; uc001mub.3; human. [Q96QD5-1]
DR CTD; 91614; -.
DR DisGeNET; 91614; -.
DR GeneCards; DEPDC7; -.
DR HGNC; HGNC:29899; DEPDC7.
DR HPA; ENSG00000121690; Group enriched (intestine, kidney, liver, testis).
DR MIM; 612294; gene.
DR neXtProt; NX_Q96QD5; -.
DR OpenTargets; ENSG00000121690; -.
DR PharmGKB; PA144596441; -.
DR VEuPathDB; HostDB:ENSG00000121690; -.
DR eggNOG; ENOG502QW4D; Eukaryota.
DR GeneTree; ENSGT00950000182976; -.
DR HOGENOM; CLU_033776_1_0_1; -.
DR InParanoid; Q96QD5; -.
DR OMA; NHIFDIH; -.
DR OrthoDB; 1481944at2759; -.
DR PhylomeDB; Q96QD5; -.
DR TreeFam; TF328365; -.
DR PathwayCommons; Q96QD5; -.
DR SignaLink; Q96QD5; -.
DR BioGRID-ORCS; 91614; 15 hits in 1077 CRISPR screens.
DR ChiTaRS; DEPDC7; human.
DR GenomeRNAi; 91614; -.
DR Pharos; Q96QD5; Tdark.
DR PRO; PR:Q96QD5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96QD5; protein.
DR Bgee; ENSG00000121690; Expressed in oocyte and 138 other tissues.
DR Genevisible; Q96QD5; HS.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00610; DEP; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..511
FT /note="DEP domain-containing protein 7"
FT /id="PRO_0000307737"
FT DOMAIN 46..136
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT VAR_SEQ 1..24
FT /note="MATVQEKAAALNLSALHSPAHRPP -> MRGLCEFYWQEFGIK (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_047180"
FT VARIANT 192
FT /note="A -> T (in dbSNP:rs34161108)"
FT /id="VAR_053972"
FT VARIANT 464
FT /note="T -> I (in dbSNP:rs17852859)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_062212"
FT CONFLICT 66
FT /note="F -> L (in Ref. 2; AAM22871)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="L -> S (in Ref. 1; CAB53247 and 2; AAM22871)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 511 AA; 58310 MW; F69089ABE41AD2EA CRC64;
MATVQEKAAA LNLSALHSPA HRPPGFSVAQ KPFGATYVWS SIINTLQTQV EVKKRRHRLK
RHNDCFVGSE AVDVIFSHLI QNKYFGDVDI PRAKVVRVCQ ALMDYKVFEA VPTKVFGKDK
KPTFEDSSCS LYRFTTIPNQ DSQLGKENKL YSPARYADAL FKSSDIRSAS LEDLWENLSL
KPANSPHVNI SATLSPQVIN EVWQEETIGR LLQLVDLPLL DSLLKQQEAV PKIPQPKRQS
TMVNSSNYLD RGILKAYSDS QEDEWLSAAI DCLEYLPDQM VVEISRSFPE QPDRTDLVKE
LLFDAIGRYY SSREPLLNHL SDVHNGIAEL LVNGKTEIAL EATQLLLKLL DFQNREEFRR
LLYFMAVAAN PSEFKLQKES DNRMVVKRIF SKAIVDNKNL SKGKTDLLVL FLMDHQKDVF
KIPGTLHKIV SVKLMAIQNG RDPNRDAGYI YCQRIDQRDY SNNTEKTTKD ELLNLLKTLD
EDSKLSAKEK KKLLGQFYKC HPDIFIEHFG D
