ID   DEPD7_MOUSE             Reviewed;         511 AA.
AC   Q91WS7; Q3TN66; Q3UNR5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=DEP domain-containing protein 7;
DE   AltName: Full=Protein TR2/D15;
GN   Name=Depdc7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Egg, Kidney, and Medulla oblongata;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=10568747; DOI=10.1101/gr.9.11.1074;
RA   Gawin B., Niederfuehr A., Schumacher N., Hummerich H., Little P.F.R.,
RA   Gessler M.;
RT   "A 7.5 Mb sequence-ready PAC contig and gene expression map of human
RT   chromosome 11p13-p14.1.";
RL   Genome Res. 9:1074-1086(1999).
CC   -!- TISSUE SPECIFICITY: Strongly expressed in liver and to a lower extent
CC       in kidney. {ECO:0000269|PubMed:10568747}.
CC   -!- SIMILARITY: Belongs to the DEPDC7 family. {ECO:0000305}.
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DR   EMBL; AK134830; BAE22303.1; -; mRNA.
DR   EMBL; AK144066; BAE25682.1; -; mRNA.
DR   EMBL; AK162218; BAE36796.1; -; mRNA.
DR   EMBL; AK165504; BAE38223.1; -; mRNA.
DR   EMBL; BX908741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC013499; AAH13499.1; -; mRNA.
DR   CCDS; CCDS16492.1; -.
DR   RefSeq; NP_659053.1; NM_144804.1.
DR   AlphaFoldDB; Q91WS7; -.
DR   SMR; Q91WS7; -.
DR   STRING; 10090.ENSMUSP00000028595; -.
DR   iPTMnet; Q91WS7; -.
DR   PhosphoSitePlus; Q91WS7; -.
DR   MaxQB; Q91WS7; -.
DR   PaxDb; Q91WS7; -.
DR   PRIDE; Q91WS7; -.
DR   ProteomicsDB; 279626; -.
DR   Antibodypedia; 6356; 158 antibodies from 21 providers.
DR   DNASU; 211896; -.
DR   Ensembl; ENSMUST00000028595; ENSMUSP00000028595; ENSMUSG00000027173.
DR   GeneID; 211896; -.
DR   KEGG; mmu:211896; -.
DR   UCSC; uc008lke.1; mouse.
DR   CTD; 91614; -.
DR   MGI; MGI:2139258; Depdc7.
DR   VEuPathDB; HostDB:ENSMUSG00000027173; -.
DR   eggNOG; ENOG502QW4D; Eukaryota.
DR   GeneTree; ENSGT00950000182976; -.
DR   HOGENOM; CLU_033776_1_0_1; -.
DR   InParanoid; Q91WS7; -.
DR   OMA; NHIFDIH; -.
DR   OrthoDB; 1481944at2759; -.
DR   PhylomeDB; Q91WS7; -.
DR   TreeFam; TF328365; -.
DR   BioGRID-ORCS; 211896; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Depdc7; mouse.
DR   PRO; PR:Q91WS7; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q91WS7; protein.
DR   Bgee; ENSMUSG00000027173; Expressed in primary oocyte and 146 other tissues.
DR   Genevisible; Q91WS7; MM.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00610; DEP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..511
FT                   /note="DEP domain-containing protein 7"
FT                   /id="PRO_0000307739"
FT   DOMAIN          46..136
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   CONFLICT        142
FT                   /note="N -> D (in Ref. 1; BAE25682)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   511 AA;  58479 MW;  1452D5B03C5B1362 CRC64;
     MATVREKAAA LNLSALHSPA QRPPGFSVAQ KPFGATYVWS SIINTLQTQV EVKKRRHHLK
     RHNDCFVGSE AVDVIYSHLT QNKFFGDVDI PRAKVVRVCQ ALMDYKVFEA VQTRVFGKDK
     KPTFEDSSCS LYRFTTIPNQ DNQLGHENKV HSPSRYSDAS FMSSDIKSDS LEDLWENLSL
     KPASSPHIHI STRLSPQVIN EVWQEETIGR LLQLVDLPFL DSLLKQQEVV PKAPQSKRQP
     DMVNTSNYLD RGILRAYGDS QEDEWISAAI DCLEYLPDQM VVDISRNFPE QPDRTDLVKE
     LLFDAIGRYY STREPLLNHL YDVHNGIAEL LVNGKTEMAL EATQLFLKLQ DSQNREEFRR
     LLYFMAVAAD PSEFKLQEES DNRMVVKRVF SKAIVNNKNV SKGKTDLLVL FLMDHQKDVF
     KIPAALHKIV SVKLLAIQKG RDPNKDTGYI YCQRIDESEY SSSTKKKTKD QLLSLLKTID
     EDSKLSAKEK KKLLGQFRKT HPDIFTEYFG D