DEPP1_HUMAN
ID DEPP1_HUMAN Reviewed; 212 AA.
AC Q9NTK1; B2R6A1; O94997; Q5T735; Q76MX8;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein DEPP1 {ECO:0000305};
DE AltName: Full=Decidual protein induced by progesterone {ECO:0000303|PubMed:16123073};
DE AltName: Full=Fasting-induced gene protein {ECO:0000303|Ref.2};
DE Short=FIG {ECO:0000303|Ref.2};
GN Name=DEPP1 {ECO:0000312|HGNC:HGNC:23355};
GN Synonyms=C10orf10, DEPP {ECO:0000303|PubMed:16123073}, FIG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Endometrium;
RX PubMed=16123073; DOI=10.1093/molehr/gah186;
RA Watanabe H., Nonoguchi K., Sakurai T., Masuda T., Itoh K., Fujita J.;
RT "A novel protein Depp, which is induced by progesterone in human
RT endometrial stromal cells activates Elk-1 transcription factor.";
RL Mol. Hum. Reprod. 11:471-476(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Adipose tissue;
RA Matsuda M., Kuriyama H., Kishida K., Funahashi T., Shimomura I.,
RA Yamashita S., Matsuzawa Y.;
RT "Molecular cloning and characterization of a novel fasting induced gene
RT transcript from adipose tissue.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INDUCTION BY HYPOXIA.
RX PubMed=21510935; DOI=10.1016/j.febslet.2011.04.024;
RA Chen S., Gai J., Wang Y., Li H.;
RT "FoxO regulates expression of decidual protein induced by progesterone
RT (DEPP) in human endothelial cells.";
RL FEBS Lett. 585:1796-1800(2011).
RN [9]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24530860; DOI=10.1016/j.bbamcr.2014.02.003;
RA Stepp M.W., Folz R.J., Yu J., Zelko I.N.;
RT "The c10orf10 gene product is a new link between oxidative stress and
RT autophagy.";
RL Biochim. Biophys. Acta 1843:1076-1088(2014).
RN [10]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=25261981; DOI=10.1186/1476-4598-13-224;
RA Salcher S., Hagenbuchner J., Geiger K., Seiter M.A., Rainer J., Kofler R.,
RA Hermann M., Kiechl-Kohlendorfer U., Ausserlechner M.J., Obexer P.;
RT "C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-
RT sensitivity in human neuroblastoma.";
RL Mol. Cancer 13:224-224(2014).
RN [11]
RP FUNCTION, AND INDUCTION.
RX PubMed=28545464; DOI=10.1186/s12943-017-0661-4;
RA Salcher S., Hermann M., Kiechl-Kohlendorfer U., Ausserlechner M.J.,
RA Obexer P.;
RT "C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-
RT induced autophagy.";
RL Mol. Cancer 16:95-95(2017).
CC -!- FUNCTION: Acts as a critical modulator of FOXO3-induced autophagy via
CC increased cellular ROS. {ECO:0000269|PubMed:24530860,
CC ECO:0000269|PubMed:25261981, ECO:0000269|PubMed:28545464}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24530860,
CC ECO:0000269|PubMed:25261981}. Peroxisome {ECO:0000269|PubMed:25261981}.
CC Mitochondrion {ECO:0000269|PubMed:25261981}. Note=May localize to
CC aggresomes (PubMed:24530860). {ECO:0000269|PubMed:24530860}.
CC -!- TISSUE SPECIFICITY: Expressed in various tissues, including pancreas,
CC placenta, ovary, testis and kidney. {ECO:0000269|PubMed:16123073}.
CC -!- DEVELOPMENTAL STAGE: High levels in first trimester deciduas. Higher
CC levels in the endometria during secretory phase than the proliferative
CC phase, especially after the mid-secretory phase.
CC {ECO:0000269|PubMed:16123073}.
CC -!- INDUCTION: By progesterone, testosterone and, to a much lower extent,
CC estrogen. Induced by oxidative stress via FOXO3 activation
CC (PubMed:28545464). Up-regulated by hypoxia (at protein level).
CC {ECO:0000269|PubMed:16123073, ECO:0000269|PubMed:21510935,
CC ECO:0000269|PubMed:28545464}.
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DR EMBL; AB022718; BAA74504.1; -; mRNA.
DR EMBL; AB025244; BAC87794.1; -; mRNA.
DR EMBL; AL136653; CAB66588.1; -; mRNA.
DR EMBL; AK002191; BAG51027.1; -; mRNA.
DR EMBL; AK312496; BAG35398.1; -; mRNA.
DR EMBL; AL353801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471160; EAW86629.1; -; Genomic_DNA.
DR EMBL; BC011402; AAH11402.1; -; mRNA.
DR CCDS; CCDS7210.1; -.
DR PIR; T46271; T46271.
DR RefSeq; NP_008952.1; NM_007021.3.
DR AlphaFoldDB; Q9NTK1; -.
DR BioGRID; 116251; 8.
DR IntAct; Q9NTK1; 9.
DR STRING; 9606.ENSP00000298295; -.
DR iPTMnet; Q9NTK1; -.
DR PhosphoSitePlus; Q9NTK1; -.
DR BioMuta; C10orf10; -.
DR DMDM; 68565547; -.
DR MassIVE; Q9NTK1; -.
DR PaxDb; Q9NTK1; -.
DR PeptideAtlas; Q9NTK1; -.
DR PRIDE; Q9NTK1; -.
DR Antibodypedia; 62493; 27 antibodies from 12 providers.
DR DNASU; 11067; -.
DR Ensembl; ENST00000298295.4; ENSP00000298295.3; ENSG00000165507.9.
DR GeneID; 11067; -.
DR KEGG; hsa:11067; -.
DR MANE-Select; ENST00000298295.4; ENSP00000298295.3; NM_007021.4; NP_008952.1.
DR UCSC; uc001jbr.5; human.
DR CTD; 11067; -.
DR DisGeNET; 11067; -.
DR GeneCards; DEPP1; -.
DR HGNC; HGNC:23355; DEPP1.
DR HPA; ENSG00000165507; Tissue enhanced (adipose tissue, breast).
DR MIM; 611309; gene.
DR neXtProt; NX_Q9NTK1; -.
DR OpenTargets; ENSG00000165507; -.
DR PharmGKB; PA128394583; -.
DR VEuPathDB; HostDB:ENSG00000165507; -.
DR eggNOG; ENOG502T1TA; Eukaryota.
DR GeneTree; ENSGT00390000017909; -.
DR HOGENOM; CLU_114587_0_0_1; -.
DR InParanoid; Q9NTK1; -.
DR OMA; PHRQMDS; -.
DR OrthoDB; 1043350at2759; -.
DR PhylomeDB; Q9NTK1; -.
DR PathwayCommons; Q9NTK1; -.
DR SignaLink; Q9NTK1; -.
DR BioGRID-ORCS; 11067; 16 hits in 1067 CRISPR screens.
DR ChiTaRS; DEPP1; human.
DR GeneWiki; C10orf10; -.
DR GenomeRNAi; 11067; -.
DR Pharos; Q9NTK1; Tbio.
DR PRO; PR:Q9NTK1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9NTK1; protein.
DR Bgee; ENSG00000165507; Expressed in type B pancreatic cell and 195 other tissues.
DR ExpressionAtlas; Q9NTK1; baseline and differential.
DR Genevisible; Q9NTK1; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IDA:UniProtKB.
DR InterPro; IPR020133; DEPP.
DR PANTHER; PTHR15426; PTHR15426; 1.
DR Pfam; PF15343; DEPP; 1.
PE 1: Evidence at protein level;
KW Autophagy; Cytoplasm; Mitochondrion; Peroxisome; Reference proteome.
FT CHAIN 1..212
FT /note="Protein DEPP1"
FT /id="PRO_0000079867"
FT REGION 20..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 44
FT /note="I -> M (in dbSNP:rs11555140)"
FT /id="VAR_050951"
FT CONFLICT 137..139
FT /note="RQM -> QTDS (in Ref. 2; BAC87794)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="M -> T (in Ref. 3; CAB66588)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 212 AA; 23406 MW; 9EEF82C7E15638A0 CRC64;
MRSRLLLSVA HLPTIRETTE EMLLGGPGQE PPPSPSLDDY VRSISRLAQP TSVLDKATAQ
GQPRPPHRPA QACRKGRPAV SLRDITARFS GQQPTLPMAD TVDPLDWLFG ESQEKQPSQR
DLPRRTGPSA GLWGPHRQMD SSKPMGAPRG RLCEARMPGH SLARPPQDGQ QSSDLRSWTF
GQSAQAMASR HRPRPSSVLR TLYSHLPVIH EL
