ID   DER21_MAIZE             Reviewed;         249 AA.
AC   Q4G2J4; Q4G2J8;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Derlin-2.1;
DE   AltName: Full=ZmDerlin2-1;
GN   Name=DER2.1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=cv. LH132;
RX   PubMed=15849299; DOI=10.1104/pp.105.060087;
RA   Kirst M.E., Meyer D.J., Gibbon B.C., Jung R., Boston R.S.;
RT   "Identification and characterization of endoplasmic reticulum-associated
RT   degradation proteins differentially affected by endoplasmic reticulum
RT   stress.";
RL   Plant Physiol. 138:218-231(2005).
CC   -!- FUNCTION: May be involved in the degradation process of specific
CC       misfolded endoplasmic reticulum (ER) luminal proteins.
CC       {ECO:0000269|PubMed:15849299}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:15849299}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:15849299}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stalks, leaves, embryo and
CC       endosperm. {ECO:0000269|PubMed:15849299}.
CC   -!- INDUCTION: By endoplasmic reticulum stress.
CC       {ECO:0000269|PubMed:15849299}.
CC   -!- MISCELLANEOUS: Associated with ER-derived protein bodies in endosperm.
CC   -!- SIMILARITY: Belongs to the derlin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY41614.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY854015; AAY41610.1; -; mRNA.
DR   EMBL; AY854019; AAY41614.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001105798.1; NM_001112328.1.
DR   AlphaFoldDB; Q4G2J4; -.
DR   SMR; Q4G2J4; -.
DR   STRING; 4577.GRMZM2G082976_P01; -.
DR   PaxDb; Q4G2J4; -.
DR   EnsemblPlants; Zm00001eb210630_T001; Zm00001eb210630_P001; Zm00001eb210630.
DR   GeneID; 606471; -.
DR   Gramene; Zm00001eb210630_T001; Zm00001eb210630_P001; Zm00001eb210630.
DR   KEGG; zma:606471; -.
DR   eggNOG; KOG0858; Eukaryota.
DR   HOGENOM; CLU_051898_5_2_1; -.
DR   OMA; WSKRNPL; -.
DR   OrthoDB; 1609512at2759; -.
DR   Proteomes; UP000007305; Chromosome 5.
DR   ExpressionAtlas; Q4G2J4; baseline and differential.
DR   Genevisible; Q4G2J4; ZM.
DR   GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR007599; DER1.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   Pfam; PF04511; DER1; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Stress response;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..249
FT                   /note="Derlin-2.1"
FT                   /id="PRO_0000249243"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..96
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..152
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   249 AA;  28507 MW;  B2A1B62985FD9F36 CRC64;
     MAQAVEEWYR QMPIITRSYL TAAVVTTVGC TLEIISPYHL YLNPKLVVQH YEIWRLVTNF
     LYFRKMDLDF LFHMFFLARY CKLLEENSFR GRTADFFYML LFGATVLTSI VLIGGMIPYI
     SETFARILFL SNSLTFMMVY VWSKHNPFIH MSFLGLFTFT AAYLPWVLLG FSILVGSSTW
     VDLLGMIAGH VYYFLEDVYP RMTGRRPLKT PSFIKALFAD DNVVVAQPPN AGIGAGARFG
     AMGLDPQAQ