ID   DERM_BIOGL              Reviewed;         148 AA.
AC   P83553;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Dermatopontin;
DE   AltName: Full=Tyrosine-rich acidic matrix protein;
DE            Short=TRAMP;
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND GLYCOSYLATION AT ASN-44.
RC   TISSUE=Shell {ECO:0000269|PubMed:12922172};
RX   PubMed=12922172; DOI=10.1016/s1570-9639(03)00203-6;
RA   Marxen J.C., Nimtz M., Becker W., Mann K.;
RT   "The major soluble 19.6 kDa protein of the organic shell matrix of the
RT   freshwater snail Biomphalaria glabrata is an N-glycosylated
RT   dermatopontin.";
RL   Biochim. Biophys. Acta 1650:92-98(2003).
CC   -!- FUNCTION: Seems to mediate adhesion by cell surface integrin binding.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000269|PubMed:12922172}.
CC   -!- PTM: The terminal mannose residues of the polysaccharide are 3-O-
CC       methylated. No tyrosine sulfation was detected.
CC   -!- SIMILARITY: Belongs to the dermatopontin family.
CC       {ECO:0000250|UniProtKB:Q07507}.
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DR   AlphaFoldDB; P83553; -.
DR   iPTMnet; P83553; -.
DR   VEuPathDB; VectorBase:BGLB012931; -.
DR   Proteomes; UP000076420; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR026645; Dermatopontin_fam.
DR   PANTHER; PTHR15040; PTHR15040; 1.
DR   Pfam; PF14704; DERM; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Direct protein sequencing; Disulfide bond;
KW   Extracellular matrix; Glycoprotein; Secreted.
FT   CHAIN           1..148
FT                   /note="Dermatopontin"
FT                   /id="PRO_0000145480"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:12922172"
FT   DISULFID        14..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..93
FT                   /note="Or C-66 with C-92"
FT                   /evidence="ECO:0000250"
FT   DISULFID        103..147
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   148 AA;  16602 MW;  F04CEFC42A01DBD2 CRC64;
     AYINLPGQPF DFQCPAGQVI SRVSSVYDVL LEDRQWEFGC RTENVTQTCS TSGYANDFGL
     PLSYSCPGKK VLTGIRSYHD NQIEDRRFTF RCCDVMSKAT TGCHVSEQVN QFNGPMLLEV
     SAGQAIKGAI SQHDVAFEDR VWKFKLCK