DERM_HUMAN
ID DERM_HUMAN Reviewed; 201 AA.
AC Q07507; A8K981; Q8N4R2; Q9UIX8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 13-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Dermatopontin;
DE AltName: Full=Tyrosine-rich acidic matrix protein;
DE Short=TRAMP;
DE Flags: Precursor;
GN Name=DPT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=8104875; DOI=10.1006/geno.1993.1348;
RA Superti-Furga A., Rocchi M., Schaefer B.W., Gitzelmann R.;
RT "Complementary DNA sequence and chromosomal mapping of a human
RT proteoglycan-binding cell-adhesion protein (dermatopontin).";
RL Genomics 17:463-467(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=10233760; DOI=10.1046/j.1523-1747.1999.00563.x;
RA Kuroda K., Okamoto O., Shinkai H.;
RT "Dermatopontin expression is decreased in hypertrophic scar and systemic
RT sclerosis skin fibroblasts and is regulated by transforming growth factor-
RT beta1, interleukin-4, and matrix collagen.";
RL J. Invest. Dermatol. 112:706-710(1999).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Seems to mediate adhesion by cell surface integrin binding.
CC May serve as a communication link between the dermal fibroblast cell
CC surface and its extracellular matrix environment. Enhances TGFB1
CC activity. Inhibits cell proliferation. Accelerates collagen fibril
CC formation, and stabilizes collagen fibrils against low-temperature
CC dissociation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TGFB1, DCN and collagen. {ECO:0000250}.
CC -!- INTERACTION:
CC Q07507; PRO_0000018520 [P28300]: LOX; NbExp=2; IntAct=EBI-719535, EBI-20724846;
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in fibroblasts, heart, skeletal muscle,
CC brain and pancreas. Expressed at an intermediate level in lung and
CC kidney, and at a low level in liver and placenta. Expressed at a lower
CC level in fibroblasts from hypertrophic scar lesional skin and in
CC fibroblasts from patients with systemic sclerosis than in normal skin
CC fibroblasts. {ECO:0000269|PubMed:10233760, ECO:0000269|PubMed:8104875}.
CC -!- INDUCTION: Induced by TGFB1, repressed by IL4/interleukin-4.
CC {ECO:0000269|PubMed:10233760}.
CC -!- PTM: Sulfated on tyrosine residue(s). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dermatopontin family. {ECO:0000305}.
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DR EMBL; Z22865; CAA80487.1; -; mRNA.
DR EMBL; AK292596; BAF85285.1; -; mRNA.
DR EMBL; AL049798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90830.1; -; Genomic_DNA.
DR EMBL; BC033736; AAH33736.1; -; mRNA.
DR CCDS; CCDS1275.1; -.
DR PIR; A47220; A47220.
DR RefSeq; NP_001928.2; NM_001937.4.
DR AlphaFoldDB; Q07507; -.
DR BioGRID; 108139; 1.
DR IntAct; Q07507; 4.
DR STRING; 9606.ENSP00000356791; -.
DR GlyGen; Q07507; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q07507; -.
DR PhosphoSitePlus; Q07507; -.
DR BioMuta; DPT; -.
DR jPOST; Q07507; -.
DR MassIVE; Q07507; -.
DR PaxDb; Q07507; -.
DR PeptideAtlas; Q07507; -.
DR PRIDE; Q07507; -.
DR ProteomicsDB; 58518; -.
DR Antibodypedia; 34354; 168 antibodies from 30 providers.
DR DNASU; 1805; -.
DR Ensembl; ENST00000367817.4; ENSP00000356791.3; ENSG00000143196.5.
DR GeneID; 1805; -.
DR KEGG; hsa:1805; -.
DR MANE-Select; ENST00000367817.4; ENSP00000356791.3; NM_001937.5; NP_001928.2.
DR UCSC; uc001gfp.4; human.
DR CTD; 1805; -.
DR DisGeNET; 1805; -.
DR GeneCards; DPT; -.
DR HGNC; HGNC:3011; DPT.
DR HPA; ENSG00000143196; Low tissue specificity.
DR MIM; 125597; gene.
DR neXtProt; NX_Q07507; -.
DR OpenTargets; ENSG00000143196; -.
DR PharmGKB; PA27471; -.
DR VEuPathDB; HostDB:ENSG00000143196; -.
DR eggNOG; ENOG502RTKC; Eukaryota.
DR GeneTree; ENSGT00390000010760; -.
DR HOGENOM; CLU_122082_1_0_1; -.
DR InParanoid; Q07507; -.
DR OMA; QGFSFQC; -.
DR OrthoDB; 1271391at2759; -.
DR PhylomeDB; Q07507; -.
DR TreeFam; TF328602; -.
DR PathwayCommons; Q07507; -.
DR SignaLink; Q07507; -.
DR BioGRID-ORCS; 1805; 10 hits in 1065 CRISPR screens.
DR ChiTaRS; DPT; human.
DR GeneWiki; Dermatopontin; -.
DR GenomeRNAi; 1805; -.
DR Pharos; Q07507; Tbio.
DR PRO; PR:Q07507; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q07507; protein.
DR Bgee; ENSG00000143196; Expressed in smooth muscle tissue and 90 other tissues.
DR Genevisible; Q07507; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0005201; F:extracellular matrix structural constituent; ISS:BHF-UCL.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030199; P:collagen fibril organization; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR InterPro; IPR026645; Dermatopontin_fam.
DR PANTHER; PTHR15040; PTHR15040; 1.
DR Pfam; PF14704; DERM; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Disulfide bond; Extracellular matrix;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal;
KW Sulfation.
FT SIGNAL 1..18
FT /evidence="ECO:0000250"
FT CHAIN 19..201
FT /note="Dermatopontin"
FT /id="PRO_0000007368"
FT REPEAT 26..79
FT /note="1-1"
FT REPEAT 70..75
FT /note="2-1"
FT REPEAT 80..135
FT /note="1-2"
FT REPEAT 125..130
FT /note="2-2"
FT REPEAT 181..186
FT /note="3-3"
FT REGION 26..186
FT /note="2 X 53-55 AA tandem repeats"
FT REGION 70..186
FT /note="3 X 6 AA repeats of D-R-[EQ]-W-[NQK]-[FY]"
FT MOD_RES 19
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P19427"
FT MOD_RES 23
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000255"
FT MOD_RES 162
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000255"
FT MOD_RES 164
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000255"
FT MOD_RES 166
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000255"
FT MOD_RES 167
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000255"
FT MOD_RES 194
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000255"
FT DISULFID 50..77
FT /evidence="ECO:0000250"
FT DISULFID 90..132
FT /note="Or C-90 with C-133"
FT /evidence="ECO:0000250"
FT DISULFID 106..133
FT /note="Or C-106 with C-132"
FT /evidence="ECO:0000250"
FT DISULFID 139..196
FT /evidence="ECO:0000250"
FT DISULFID 143..189
FT /evidence="ECO:0000255"
FT VARIANT 201
FT /note="V -> I (in dbSNP:rs6698023)"
FT /id="VAR_048888"
FT CONFLICT 10
FT /note="L -> M (in Ref. 1; CAA80487)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="T -> I (in Ref. 5; AAH33736)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 201 AA; 24005 MW; C886D2FB624DDB49 CRC64;
MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC PQGQVIVAVR
SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM EWYQTCSNNG LVAGFQSRYF
ESVLDREWQF YCCRYSKRCP YSCWLTTEYP GHYGEEMDMI SYNYDYYIRG ATTTFSAVER
DRQWKFIMCR MTEYDCEFAN V
