ID   DERP3_DERPT             Reviewed;         261 AA.
AC   P39675;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Mite allergen Der p 3;
DE            EC=3.4.21.-;
DE   AltName: Full=Allergen Der p III;
DE   AltName: Allergen=Der p 3;
DE   Flags: Precursor;
GN   Name=DERP3;
OS   Dermatophagoides pteronyssinus (European house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX   NCBI_TaxID=6956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 30-59.
RX   PubMed=8012853; DOI=10.1111/j.1365-2222.1994.tb00223.x;
RA   Smith W.-A., Chua K.-Y., Kuo M.C., Rogers B.L., Thomas W.R.;
RT   "Cloning and sequencing of the Dermatophagoides pteronyssinus group III
RT   allergen, Der p III.";
RL   Clin. Exp. Allergy 24:220-228(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 30-47 AND 223-229.
RX   PubMed=1537598;
RA   Stewart G.A., Ward L.D., Simpson R.J., Thompson P.J.;
RT   "The group III allergen from the house dust mite Dermatophagoides
RT   pteronyssinus is a trypsin-like enzyme.";
RL   Immunology 75:29-35(1992).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC       allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00274}.
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DR   EMBL; U11719; AAA19973.1; -; mRNA.
DR   AlphaFoldDB; P39675; -.
DR   SMR; P39675; -.
DR   Allergome; 317; Der p 3.
DR   Allergome; 3263; Der p 3.0101.
DR   MEROPS; S01.031; -.
DR   SABIO-RK; P39675; -.
DR   Proteomes; UP000515146; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; -; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Hydrolase; Protease;
KW   Reference proteome; Secreted; Serine protease; Signal; Zymogen.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..29
FT                   /evidence="ECO:0000269|PubMed:1537598,
FT                   ECO:0000269|PubMed:8012853"
FT                   /id="PRO_0000028145"
FT   CHAIN           30..261
FT                   /note="Mite allergen Der p 3"
FT                   /id="PRO_0000028146"
FT   DOMAIN          30..260
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   ACT_SITE        69
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        114
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        214
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   SITE            208
FT                   /note="Required for specificity"
FT   DISULFID        54..70
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        181..198
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        210..236
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ   SEQUENCE   261 AA;  28060 MW;  066C7C25E0D67FBD CRC64;
     MIIYNILIVL LLAINTLANP ILPASPNATI VGGEKALAGE CPYQISLQSS SHFCGGTILD
     EYWILTAAHC VAGQTASKLS IRYNSLKHSL GGEKISVAKI FAHEKYDSYQ IDNDIALIKL
     KSPMKLNQKN AKAVGLPAKG SDVKVGDQVR VSGWGYLEEG SYSLPSELRR VDIAVVSRKE
     CNELYSKANA EVTDNMICGG DVANGGKDSC QGDSGGPVVD VKNNQVVGIV SWGYGCARKG
     YPGVYTRVGN FIDWIESKRS Q