DERPC_HUMAN
ID DERPC_HUMAN Reviewed; 524 AA.
AC P0CG12; A8MYX8; Q71E72; Q8NDH8; Q8WV66; Q9NX73;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Decreased expression in renal and prostate cancer protein {ECO:0000305};
GN Name=DERPC {ECO:0000312|HGNC:HGNC:54084};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, AND SUBCELLULAR
RP LOCATION.
RX PubMed=12477976; DOI=10.1007/bf03402176;
RA Sun M., Ma L., Xu L., Li J., Zhang W., Petrovics G., Makarem M.,
RA Sesterhenn I., Zhang M., Blanchette-Mackie E.J., Moul J., Srivastava S.,
RA Zou Z.;
RT "A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth
RT and its expression is decreased in prostate and renal tumors.";
RL Mol. Med. 8:655-663(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-310.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=18213475; DOI=10.1007/s10549-008-9905-8;
RA Green A.R., Krivinskas S., Young P., Rakha E.A., Paish E.C., Powe D.G.,
RA Ellis I.O.;
RT "Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular
RT carcinoma in situ of the breast.";
RL Breast Cancer Res. Treat. 113:59-66(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302 AND SER-423, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Potential tumor suppressor. Inhibits prostate tumor cell
CC growth, when overexpressed. {ECO:0000269|PubMed:12477976}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12477976}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with abundant expression in
CC kidney, skeletal muscle, testis, liver, ovary, and heart and moderate
CC expression in prostate. Expression is significantly reduced in renal
CC and prostate tumors. No differential expression in breast cancer cells,
CC between lobular carcinoma and normal lobules.
CC {ECO:0000269|PubMed:12477976, ECO:0000269|PubMed:18213475}.
CC -!- MISCELLANEOUS: Found in a common chromosomal region of deletion in
CC breast cancer.
CC -!- SIMILARITY: Belongs to the DERPC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD38758.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF525164; AAQ08897.1; -; mRNA.
DR EMBL; AL833902; CAD38758.1; ALT_INIT; mRNA.
DR EMBL; AC009027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW83250.1; -; Genomic_DNA.
DR EMBL; AK000407; BAA91144.1; -; mRNA.
DR RefSeq; XP_011521469.1; XM_011523167.1.
DR RefSeq; XP_011521470.1; XM_011523168.1.
DR AlphaFoldDB; P0CG12; -.
DR IntAct; P0CG12; 4.
DR GlyGen; P0CG12; 7 sites, 2 O-linked glycans (7 sites).
DR iPTMnet; P0CG12; -.
DR MetOSite; P0CG12; -.
DR PhosphoSitePlus; P0CG12; -.
DR BioMuta; CHTF8; -.
DR DMDM; 298351628; -.
DR EPD; P0CG12; -.
DR jPOST; P0CG12; -.
DR MassIVE; P0CG12; -.
DR PaxDb; P0CG12; -.
DR PeptideAtlas; P0CG12; -.
DR PRIDE; P0CG12; -.
DR Ensembl; ENST00000306585.9; ENSP00000305687.6; ENSG00000286140.2.
DR Ensembl; ENST00000519520.7; ENSP00000427718.2; ENSG00000286140.2.
DR MANE-Select; ENST00000519520.7; ENSP00000427718.2; NM_001002847.4; NP_001002847.1.
DR UCSC; uc059wiz.1; human.
DR GeneCards; DERPC; -.
DR HGNC; HGNC:54084; DERPC.
DR HPA; ENSG00000286140; Low tissue specificity.
DR MIM; 613202; gene.
DR neXtProt; NX_P0CG12; -.
DR VEuPathDB; HostDB:ENSG00000286140; -.
DR GeneTree; ENSGT00650000093476; -.
DR HOGENOM; CLU_036906_1_0_1; -.
DR InParanoid; P0CG12; -.
DR OMA; MGANSAP; -.
DR PhylomeDB; P0CG12; -.
DR PathwayCommons; P0CG12; -.
DR SignaLink; P0CG12; -.
DR BioGRID-ORCS; 54921; 367 hits in 1088 CRISPR screens.
DR ChiTaRS; CHTF8; human.
DR GenomeRNAi; 54921; -.
DR Pharos; P0CG12; Tdark.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P0CG12; protein.
DR Bgee; ENSG00000286140; Expressed in ganglionic eminence and 93 other tissues.
DR Genevisible; P0CG12; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
PE 1: Evidence at protein level;
KW Methylation; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..524
FT /note="Decreased expression in renal and prostate cancer
FT protein"
FT /id="PRO_0000326396"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 302
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 364
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:P0CG14"
FT MOD_RES 387
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P0CG14"
FT MOD_RES 423
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 524 AA; 51391 MW; C917FEEC7BC3702E CRC64;
MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP FLMAAGSLGG
NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR GMNPTGTGAV SFPRPGGLLG
PGPGPGPTLN PRTGALPGPG PLSNPRLGGL PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG
SGPNLRAGVL LTSGNGPPNP RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP
SGLGPGPNLD ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG
TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR PVGPMGVNAN
PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP RASGPLGPNP ANFPRATGLQ
GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG PSPAGPVGIN PAPFTRPTGT LGLNPASFPR
MNGPAGKSFV PFPRVGSLPG TNPAAFPRPG GPMAAMYPNG MLPP
