DERPC_MOUSE
ID DERPC_MOUSE Reviewed; 533 AA.
AC P0CG14; P0C6T0; Q8BHM2; Q8R5A5;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Decreased expression in renal and prostate cancer protein {ECO:0000250|UniProtKB:P0CG12};
GN Name=Derpc {ECO:0000250|UniProtKB:P0CG12};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-368 AND ARG-396, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Potential tumor suppressor. {ECO:0000250|UniProtKB:P0CG12}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0CG12}.
CC -!- SIMILARITY: Belongs to the DERPC family. {ECO:0000305}.
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DR EMBL; AK030924; BAC27186.1; -; mRNA.
DR EMBL; AK088257; BAC40241.1; -; mRNA.
DR EMBL; AK165993; BAE38506.1; -; mRNA.
DR EMBL; AC140328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC023107; AAH23107.1; -; mRNA.
DR RefSeq; NP_663387.3; NM_145412.3.
DR RefSeq; XP_017168143.1; XM_017312654.1.
DR RefSeq; XP_017168144.1; XM_017312655.1.
DR RefSeq; XP_017168145.1; XM_017312656.1.
DR AlphaFoldDB; P0CG14; -.
DR BioGRID; 229585; 2.
DR STRING; 10090.ENSMUSP00000129823; -.
DR iPTMnet; P0CG14; -.
DR PhosphoSitePlus; P0CG14; -.
DR EPD; P0CG14; -.
DR jPOST; P0CG14; -.
DR PeptideAtlas; P0CG14; -.
DR PRIDE; P0CG14; -.
DR ProteomicsDB; 285392; -.
DR Ensembl; ENSMUST00000169312; ENSMUSP00000129823; ENSMUSG00000117748.
DR GeneID; 214987; -.
DR KEGG; mmu:214987; -.
DR UCSC; uc009ngq.1; mouse.
DR CTD; 54921; -.
DR VEuPathDB; HostDB:ENSMUSG00000117748; -.
DR eggNOG; ENOG502SV5R; Eukaryota.
DR GeneTree; ENSGT00650000093476; -.
DR HOGENOM; CLU_036906_1_0_1; -.
DR InParanoid; P0CG14; -.
DR OMA; MGANSAP; -.
DR PhylomeDB; P0CG14; -.
DR TreeFam; TF338736; -.
DR BioGRID-ORCS; 214987; 15 hits in 73 CRISPR screens.
DR ChiTaRS; Chtf8; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P0CG14; protein.
DR Bgee; ENSMUSG00000117748; Expressed in epiblast (generic) and 59 other tissues.
DR Genevisible; P0CG14; MM.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
PE 1: Evidence at protein level;
KW Methylation; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..533
FT /note="Decreased expression in renal and prostate cancer
FT protein"
FT /id="PRO_0000326397"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..126
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RYL1"
FT MOD_RES 368
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 396
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P0CG12"
FT CONFLICT 28
FT /note="G -> E (in Ref. 3; AAH23107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 533 AA; 52244 MW; 0399DF3ABE73C5F6 CRC64;
MKEPRIFPRE RPTPWTRAPL PPRGRLDGGP VMNAGHPMGV NSDPFLMAAG SLGGNLAPFP
RNAAPFQNPS GSLASNPAHF AAGARDPGMT SFPRGMNPTG TGAVSFPRPG GLLGPGPGPG
LNPRTGALPG PGPMSNPRLG GLPGPGPMAN PRAGGLLGAS PDPRSGGPMV PGCGPNMRAG
VLSSGTGPPN PRPVGLGPGP SPNLRSSFLG TNPAPRSGMF PGPGLGPNPR ACGLGPGLGP
NPRAGGLGPG PNLDNRAGGL LGTGSGLNLR MAGPQGLDLA PILRAAGLLG TNSVSFSQAS
GNMGTNPPTM TRVPGPIGPN TGPSSRGLGL PGPNPSPMSR APGPMGPNSA HFSRPGGPMG
VNAGVFPRGT GSGGLNPNAF SQSSGTLASN PGTFQRSAGL QGSNQAVFPR ASGPLGPNPA
NFPRATGLQG PSPAAFPRSA GPLGPGQVAF PRSAAGHLGS SPAGPVGINP APFARPTGTL
GLNPASFPRM NGPVGKTLVP FPRVGSLPGS NPAAFPRPGG PMAAMYPNGM LPP
