ID   DERPC_RAT               Reviewed;         533 AA.
AC   B2RYL1;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Decreased expression in renal and prostate cancer protein {ECO:0000250|UniProtKB:P0CG12};
GN   Name=Derpc {ECO:0000250|UniProtKB:P0CG12};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:EDL92457.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAI66818.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAI66818.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Potential tumor suppressor. {ECO:0000250|UniProtKB:P0CG12}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0CG12}.
CC   -!- SIMILARITY: Belongs to the DERPC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH473972; EDL92457.1; -; Genomic_DNA.
DR   EMBL; CH473972; EDL92458.1; -; Genomic_DNA.
DR   EMBL; BC166818; AAI66818.1; -; mRNA.
DR   AlphaFoldDB; B2RYL1; -.
DR   IntAct; B2RYL1; 1.
DR   MINT; B2RYL1; -.
DR   iPTMnet; B2RYL1; -.
DR   PhosphoSitePlus; B2RYL1; -.
DR   PaxDb; B2RYL1; -.
DR   PeptideAtlas; B2RYL1; -.
DR   PRIDE; B2RYL1; -.
DR   Ensembl; ENSRNOT00000070822; ENSRNOP00000063969; ENSRNOG00000047246.
DR   Ensembl; ENSRNOT00000111805; ENSRNOP00000096000; ENSRNOG00000047246.
DR   eggNOG; ENOG502SV5R; Eukaryota.
DR   GeneTree; ENSGT00650000093476; -.
DR   HOGENOM; CLU_066293_3_0_1; -.
DR   InParanoid; B2RYL1; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Proteomes; UP000234681; Chromosome 19.
DR   Genevisible; B2RYL1; RN.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
PE   1: Evidence at protein level;
KW   Methylation; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..533
FT                   /note="Decreased expression in renal and prostate cancer
FT                   protein"
FT                   /id="PRO_0000394970"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          370..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         160
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         368
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P0CG14"
FT   MOD_RES         396
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P0CG14"
FT   MOD_RES         432
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P0CG12"
SQ   SEQUENCE   533 AA;  52095 MW;  9E8C3A36AD976AD8 CRC64;
     MKEPRIFPRE RPTPWTRAPL PPRGRLDGGP GVNAGHPMGV NTDPFLMAAG SLGGNLAPFA
     RNPAPFPTPS GSLASNPAHF PAGARDPSMT SFPRGMNPTG TGAASFPRPG GLLGPGPGPG
     LNPRTGALPG SGPMSNPRLG GLPGPGPMAN PRAGGLLGAS PDPRSGGPMG PGCGPNMRAG
     VLSSGTGPPN PRPMGLGPGP SPNLRSSFLG TNPAPRPGMF PGPGLGPNPR ACGLGPGLGP
     NPRAGGLGPG PNLDNRAGGL LGTGSGLNLR MAGPQGLDLA PILRAAGLLG TNSVSFSQAS
     GNMGTNPPTM TRVPGPIGPN TGPSSRGIGL SGPNPSAMSR APGPMGPNSA HFSRPGGPMG
     VNAGVFPRGT GSGGLNPAAF SQSSGTLSSN PGTFQRSAGL QGSNQAVFPR ASGPLGPNPA
     NFPRATGLQG PSPAAFPRSA GPLGPGQVAF PRSAAGHLGS SPAGPVGINP APFARPTGTL
     GLNPASFPRM NGPVGKTLVP FPRVGSLPGS NPAAFPRPGG PMAAMYPNGM LPP