DER_ACTP7
ID DER_ACTP7 Reviewed; 506 AA.
AC B3H0R7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=APP7_0427;
OS Actinobacillus pleuropneumoniae serotype 7 (strain AP76).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=537457;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP76;
RA Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N.,
RA Tegetmeyer H., Singh M., Gerlach G.F.;
RT "Genome and proteome analysis of A. pleuropneumoniae serotype 7.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; CP001091; ACE61079.1; -; Genomic_DNA.
DR RefSeq; WP_005616842.1; NC_010939.1.
DR AlphaFoldDB; B3H0R7; -.
DR SMR; B3H0R7; -.
DR EnsemblBacteria; ACE61079; ACE61079; APP7_0427.
DR KEGG; apa:APP7_0427; -.
DR HOGENOM; CLU_016077_5_1_6; -.
DR OMA; KFRFLEY; -.
DR BioCyc; APLE537457:APP7_RS02175-MON; -.
DR Proteomes; UP000001226; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Repeat; Ribosome biogenesis.
FT CHAIN 1..506
FT /note="GTPase Der"
FT /id="PRO_1000099084"
FT DOMAIN 3..166
FT /note="EngA-type G 1"
FT DOMAIN 218..391
FT /note="EngA-type G 2"
FT DOMAIN 392..476
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 56..60
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 118..121
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 224..231
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 271..275
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 336..339
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 506 AA; 56175 MW; BA2D7D32511D2A3C CRC64;
MTPVVALVGR PNVGKSTLFN RLTRTRDALV ADFPGLTRDR KYGHANIAGY DFIVIDTGGI
DGTEEGVEEK MAEQSLLAIE EADVVLFLVD ARAGLVPADI GIAQYLRQRE KTTVVVANKT
DGIDADSHCA EFYQLGLGEV EQIAAAQGRG VTQLIDQVLA PLGEQLNADQ AVENEENSAN
EEADEWDTDF DFENEDDTAL LDEALEEETE ESIEDKNIKI AIVGRPNVGK STLTNRILGE
ERVVVYDMPG TTRDSIYIPM ERDGQQYTII DTAGVRKRGK VNLAVEKFSV IKTLQAIQDA
NVVLLTIDAR EGISDQDLSL LGFILNAGRS LVIVVNKWDG LSQDIKDQVK SELDRRLDFI
DFARVHFISA LHGSGVGNLF DSVKEAYACA TQKNSTSMLT RILRMAADEH QPPLVNGRRV
KLKYAHPGGY NPPIIVIHGN QVEKLADSYK RYLSNYFRKS LKIIGSPIRI QFQEGNNPFA
GKKNKLTPSQ LRKRKRLMKF IKKSKK
