DER_AKKM8
ID DER_AKKM8 Reviewed; 464 AA.
AC B2UMV5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=Amuc_0319;
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP
RC 107961 / Muc;
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; CP001071; ACD04161.1; -; Genomic_DNA.
DR RefSeq; WP_012419376.1; NC_010655.1.
DR AlphaFoldDB; B2UMV5; -.
DR SMR; B2UMV5; -.
DR STRING; 349741.Amuc_0319; -.
DR EnsemblBacteria; ACD04161; ACD04161; Amuc_0319.
DR GeneID; 60879797; -.
DR KEGG; amu:Amuc_0319; -.
DR eggNOG; COG1160; Bacteria.
DR HOGENOM; CLU_016077_6_2_0; -.
DR OMA; KFRFLEY; -.
DR OrthoDB; 263682at2; -.
DR BioCyc; AMUC349741:G1GBX-361-MON; -.
DR Proteomes; UP000001031; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW Ribosome biogenesis.
FT CHAIN 1..464
FT /note="GTPase Der"
FT /id="PRO_1000099086"
FT DOMAIN 5..169
FT /note="EngA-type G 1"
FT DOMAIN 190..368
FT /note="EngA-type G 2"
FT DOMAIN 369..461
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 11..18
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 58..62
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 196..203
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 243..247
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 308..311
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 464 AA; 51389 MW; 8205A40680C26C67 CRC64;
MQHVPTIAIV GRPNVGKSAI FNRMAGRRIA IVHDEPGVTR DRLSAPCKIT DRACKIMDTG
GIGARLSDGF AEQVEAEADI AIKTADLILF VLDCRDHLTP IDQSIADHLR KSDIPVILLL
NKADHEKQDL NLGEFAGLGF DDHIFLSAAH GRGFSELASR LDGFLKQKGA PLKEELEEEP
ENGEETALPI KVAVVGRPNA GKSSLVNAIL RDRRTIVSNV AGTTRDAIDV PYLHDGQPYV
LIDTAGMRPR SRRDTSVEVF SAMRSEKAIR RADICLLVID IAAGITQQDR RIAGIIAEEG
KPCIIIVNKF DLFHPNASRK DRMAEVEEQV RRELFFISYA PFIATSAKKA EGVEIIFKVI
TRIRRESHNL PTTGQLNRLI QLAQQMNPPG AASGSARRLK IYYATTAVDP KYNTIPVPRY
VLFVNDKSLL TDSYSQYLRN KIREAYPAPG IPVIFSARSR VRND
