DER_BARHE
ID DER_BARHE Reviewed; 475 AA.
AC Q6G5J7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=BH04080;
OS Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS (Rochalimaea henselae).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=283166;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA La Scola B., Holmberg M., Andersson S.G.E.;
RT "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT of the zoonotic agent Bartonella henselae.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; BX897699; CAF27217.1; -; Genomic_DNA.
DR RefSeq; WP_011180344.1; NZ_LRIJ02000001.1.
DR AlphaFoldDB; Q6G5J7; -.
DR SMR; Q6G5J7; -.
DR STRING; 283166.BH04080; -.
DR PaxDb; Q6G5J7; -.
DR PRIDE; Q6G5J7; -.
DR EnsemblBacteria; CAF27217; CAF27217; BH04080.
DR GeneID; 64156691; -.
DR KEGG; bhe:BH04080; -.
DR eggNOG; COG1160; Bacteria.
DR OMA; KFRFLEY; -.
DR Proteomes; UP000000421; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Repeat; Ribosome biogenesis.
FT CHAIN 1..475
FT /note="GTPase Der"
FT /id="PRO_1000011568"
FT DOMAIN 3..167
FT /note="EngA-type G 1"
FT DOMAIN 205..380
FT /note="EngA-type G 2"
FT DOMAIN 381..465
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 56..60
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 119..122
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 211..218
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 258..262
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 323..326
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 475 AA; 52968 MW; D68A7959BD3B613D CRC64;
MSLTIAIVGR PNVGKSTLFN RLVGQKLALV DDKPGVTRDR RVHAATLQDL RFDVIDTAGL
EETGDHTLEG RMRAHTKAAI DEADLILFVF DAKSGITPSD LNFASLVRKS GKPIVLVANK
SESKAAIGGE YEAWSLGLGE PCSISAEHGL GLSDLRDAIM KASGGERIFA SKNQEEHIAL
QSASLDDYID NLEEKGDVYD KSKPLRIAVA GRPNTGKSTL INRMLGQDRL LTGPEAGLTR
DSISVDWEWR GRHIKLFDTA GLRRKSKIQE KLEKLSVADT LRAIRFAEVV VIVFDATTPF
EKQDLQIADL VIREGRVPLI AFNKWDLIEN SQATLVDLHE KCIRLLPQVR GLRAVPLSGQ
YGQGIDKLME NVMMMHRVWN RRISTGKLNR WLETIVAHHP PPAVLGRRLK VKYVTQVKTR
PPGFVFSCSR PKLMPQSYLR YLSNELRNTF DMPGIPIRIS LRASDNPFAT RSKKK