DER_CHLTR
ID DER_CHLTR Reviewed; 490 AA.
AC O84709;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=CT_703;
OS Chlamydia trachomatis (strain D/UW-3/Cx).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=272561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT trachomatis.";
RL Science 282:754-759(1998).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; AE001273; AAC68298.1; -; Genomic_DNA.
DR PIR; H71480; H71480.
DR RefSeq; NP_220222.1; NC_000117.1.
DR RefSeq; WP_009872078.1; NC_000117.1.
DR AlphaFoldDB; O84709; -.
DR SMR; O84709; -.
DR STRING; 813.O172_03885; -.
DR EnsemblBacteria; AAC68298; AAC68298; CT_703.
DR GeneID; 884507; -.
DR KEGG; ctr:CT_703; -.
DR PATRIC; fig|272561.5.peg.774; -.
DR HOGENOM; CLU_016077_6_2_0; -.
DR InParanoid; O84709; -.
DR OMA; KFRFLEY; -.
DR Proteomes; UP000000431; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW Ribosome biogenesis.
FT CHAIN 1..490
FT /note="GTPase Der"
FT /id="PRO_0000178982"
FT DOMAIN 1..165
FT /note="EngA-type G 1"
FT DOMAIN 227..400
FT /note="EngA-type G 2"
FT DOMAIN 401..485
FT /note="KH-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 7..14
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 54..58
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 117..120
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 233..240
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 280..284
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 345..348
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 490 AA; 55569 MW; 203A51FF454071F4 CRC64;
MRIAILGRPN VGKSSLFNRL CKRSLAIVNS QEGTTRDRLY GEIRAWDSII HVIDTGGVDQ
ESTDRFQKQI HQQALAAAEE ASVLLLVVDI RCGITKQDEE LAKRLLPLKK PLILVMNKAD
SQQDLQRIHE FYGLGISDMI ATSASHDKHI DLLLERIRQI AQIPVPSVEE QDAVQEDELP
SEEAAISLHA FADETLFENE SLSQEEASFL EELVAQTATP APVDRPLKVA LIGHPNVGKS
SIINALLKEE RCITDNSPGT TRDNIDVAYT HNNKEYVFID TAGLRKTKSI KNSVEWMSSS
RTEKAISRTD ICLLVIDATQ QLSYQDKRIL SMIARYKKPH VILVNKWDLM FGVRMEHYVQ
DLRKMDPYIG QARILCISAK QRRNLLQIFS AIDDIYTIAT TKLSTSLVNK VLASAMQRHH
PQVINGKRLR IYYAIHKTTT PFTFLLFINS NSLLTKPYEL YLKNTLKAAF NLYRVPFDLE
YKAKPARKSN
