DER_DELAS
ID DER_DELAS Reviewed; 448 AA.
AC A9BMU9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=GTPase Der {ECO:0000255|HAMAP-Rule:MF_00195};
DE AltName: Full=GTP-binding protein EngA {ECO:0000255|HAMAP-Rule:MF_00195};
GN Name=der {ECO:0000255|HAMAP-Rule:MF_00195}; Synonyms=engA;
GN OrderedLocusNames=Daci_5015;
OS Delftia acidovorans (strain DSM 14801 / SPH-1).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Delftia.
OX NCBI_TaxID=398578;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14801 / SPH-1;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P.;
RT "Complete sequence of Delftia acidovorans DSM 14801 / SPH-1.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}.
CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family. {ECO:0000255|HAMAP-
CC Rule:MF_00195}.
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DR EMBL; CP000884; ABX37644.1; -; Genomic_DNA.
DR RefSeq; WP_012206814.1; NC_010002.1.
DR AlphaFoldDB; A9BMU9; -.
DR SMR; A9BMU9; -.
DR STRING; 398578.Daci_5015; -.
DR PRIDE; A9BMU9; -.
DR EnsemblBacteria; ABX37644; ABX37644; Daci_5015.
DR KEGG; dac:Daci_5015; -.
DR eggNOG; COG1160; Bacteria.
DR HOGENOM; CLU_016077_6_2_4; -.
DR OMA; KFRFLEY; -.
DR Proteomes; UP000000784; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR031166; G_ENGA.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTP-bd_EngA.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR03594; GTPase_EngA; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 2.
DR PROSITE; PS51712; G_ENGA; 2.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome; Repeat;
KW Ribosome biogenesis.
FT CHAIN 1..448
FT /note="GTPase Der"
FT /id="PRO_1000099115"
FT DOMAIN 3..167
FT /note="EngA-type G 1"
FT DOMAIN 182..355
FT /note="EngA-type G 2"
FT BINDING 9..16
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 56..60
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 119..122
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 188..195
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 235..239
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
FT BINDING 300..303
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00195"
SQ SEQUENCE 448 AA; 49707 MW; BE0445507B270856 CRC64;
MKPVIALVGR PNVGKSTLFN RLTKSRDAIV ADFAGLTRDR HYGQGRQGKH EYIVIDTGGF
EPDASSGIFK EMARQTQQAV AEADVVVFVV DARLGMSAQD HDIAKYLRRL GKPCVLVANK
AEGMKEGVQL TEFYELGLGD VLPVSAAHGQ GVRDLLDLAL GQLNLPEPEE DDPFDDVAQK
PIRLTVAGRP NVGKSTLINT WLGEERLVAF DMPGTTRDAI SVPFERAGQK FELIDTAGLR
RKGRVFEAIE KFSVVKTLQA IESANVVLLL IDATQGVTDQ DAHIAGYVLE SGRAVVLAVN
KWDAVDDYQR QMLERSIETR LSFLKFAPMH FISAEKRQGL GPLWNSIIQA HKAATCKMPT
PVLTRLLMEA VQFQTPKKTG IYRPKMRYAH QGGMNPPVIV IHGNSLEHVT EAYKRFLEGR
FRKEFNLVGT PLRIELKTSH NPFADKDK
