靶标：
SET
产品别名：
2PP2A； I2PP2A； IGAAD； IPP2A2； MRD58； PHAPII； TAF-I； TAF-IBETA； SET； SET nuclear proto-oncogene； SET nuclear proto-oncogene； protein SET； HLA-DR-associated protein II； SET nuclear oncogene； SET translocation (myeloid leukemia-associated)； Template-Activating Factor-I, chromatin remodelling factor； chromatin remodelling factor； inhibitor of granzyme A-activated DNase； inhibitor-2 of protein phosphatase-2A； phosphatase 2A inhibitor I2PP2A； protein phosphatase type 2A inhibitor； SET易位蛋白/髓系白血病相关蛋白；
背景信息：
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
